Program leads: Kathleen Derwin, Eric Ricchetti
The Shoulder Research Program focuses on Arthroplasty and Rotator Cuff Repair surgery. Through laboratory and human subjects research, we seek to identify demographic, disease-related, biological and surgical factors associated with short- and longer-term outcomes following shoulder arthroplasty or rotator cuff repair, in both the primary and revision setting. We develop advanced imaging metrics to quantify baseline pathology, structural healing, and postoperative implant position (arthroplasty), along with treatments to improve implant longevity (arthroplasty) and tendon healing (rotator cuff repair). This includes a better understanding of factors that impact outcomes in revision shoulder arthroplasty, particularly periprosthetic joint infection, and the use of biological and structural augmentation strategies for rotator cuff repair. Our aim is to enhance patient outcomes by improving clinical decision-making, patient selection, proactive management of social and disease-related factors and optimizing surgical methods that maximize surgical healing.
Collaborators: Joseph Iannotti, Vahid Entezari, Jason Ho, Carl Winalski, Joshua Polster, Peter Imrey, Sambit Sahoo
Program leads: John Elias, Lutul Farrow, Xiaojuan Li
The Patellofemoral Disorders Research Group investigates injuries that hinder function of the patellofemoral joint, such as patellar dislocations and patellofemoral pain. The patient-focused research approach combines quantitative MRI, anatomical analysis, biomechanical modeling, and outcomes analysis to evaluate mechanisms of injury, treatment strategies and long term influence on function. Evaluating mechanisms of injury improves understanding of the functional characteristics that cause patellofemoral disorders. Treatment strategies are studied to evaluate how surgical and conservative treatment options influence joint mechanics. Evaluation of long term function primarily focuses on progressive cartilage degradation to osteoarthritis triggered by a patellofemoral disorder. The overall goals of the program are to reduce the risk of injury and optimize patient-specific treatment strategies to return patients to an active lifestyle while also preserving patellofemoral cartilage.
Collaborators: Carl Winalski, Aaron Lear, Mei Li, Mingrui Yang, Richard Lartey, James Peters, Bong-Jae Jun, Nancy Obuchowski
Program lead: M. Elaine Husni
The Inflammatory Joint Disease Research Program is dedicated to advancing our understanding and treatment of immune-mediated inflammatory arthritis through innovative approaches. Our focus lies in three key areas: (1) Early Disease Detection: We're pioneering biomarker discovery and novel imaging techniques to identify signs of arthritis at its earliest stages, allowing for prompt intervention; (2) Patient Stratification: By refining our understanding of disease burden and prognosis, we aim to better tailor treatments to individual patients, moving away from a one-size-fits-all approach; (3) Personalized Treatment: We're committed to enhancing therapeutic options by moving beyond trial and error, towards personalized treatment plans based on a patient's unique profile. To support these efforts, we've established disease-specific biorepositories housing over 20,000 samples. This invaluable resource fuels our exploration of potential risk factors for disease, targeted therapeutics, and the identification of associated comorbidities. Additionally, our translational research program using pre-clinical models synergistically examines the mechanisms of these immune-mediated diseases, fostering a comprehensive approach to improving patient outcomes.
Collaborators: Unni Chandrasekaran, Shashank Cheemalavagu, Jean Lin
Program leads: Thomas Mroz, Michael Steinmetz
The Spine Surgery Clinical Outcomes Research Program focuses on leveraging big data from the electronic medical record (EMR) of patients at Cleveland Clinic to better understand outcomes following spine surgery. Through both cadaveric biomechanics' models, computational models and retrospective and prospective clinical studies, we seek to identify demographic, disease-related, biological and surgical factors associated with short- and longer-term outcomes following spine surgery particularly focusing on patient reported outcomes for quality of life, pain, and disability. We have also developed advanced imaging metrics to quantify baseline pathology, structural healing, and postoperative success along with treatments to improve fusion quality, post-operative outcomes, patient satisfaction, and patient safety. Our aim is to enhance patient outcomes by improving clinical decision-making, patient selection, proactive management of social and disease-related factors and optimizing surgical methods that maximize surgical success.
Collaborators: Edward Benzel, Deborah Benzil, Ajit Krishnaney, Iain Kalfas, Jason Savage, Douglas Orr, Dominic Pelle, Richard Schlenk, Ghaith Habboub, Kush Goyal, Megan Jack, Mohamed Macki, Moayad Alabdulkarim, William Clifton, Jeremy Amps
Program lead: Jason A. Genin
The mission of the Interventional Sports Medicine Group is to provide integrated, team-based care for individuals with various musculoskeletal complaints and conditions, emphasizing diagnosis, treatment, prevention, and education. We are actively developing enterprise-wide guidelines and treatment protocols for various nonoperative sports medicine conditions, such as patellar tendinopathy and adhesive capsulitis. We seek to measure clinical outcomes for all interventional sports medicine procedures through a collaborative effort between physicians, physical therapists, athletic trainers, and researchers on the national and international levels.
Collaborators: Vikas Patel, Leonardo Olivieria, Matthew Mitchkash, Caitlin Lewis, Lauren Wichman, Molly McDermott, Dominic King, Michael Scarcella, Michael Dakkak, Evan Peck
Program lead: Suneel Apte
My laboratory, working closely with other scientists and clinicians at the Cleveland Clinic and elsewhere, is interested in the process of joint breakdown and inflammation in all forms of arthritis. We study human osteoarthritis and human and equine (horse) post-traumatic OA, which are thought to be degenerative in origin. We also investigate juvenile idiopathic arthritis and rheumatoid arthritis, where inflammation is the underlying cause. We analyze cartilage and synovial fluid taken from joints with these disorders using mass spectrometry based N-terminomics, which identifies the precise sites of molecular fragmentation as well as the proteases which are responsible. Our goal is to identify novel disease biomarkers, determine which proteases could be drug targets in these conditions, and understand the basic mechanisms of joint breakdown and inflammation. We are engaged in development of new technologies for biomarker detection and new drugs to target some of the principal proteases responsible for joint breakdown and inflammation.
Collaborators: Sumit Bhutada, Nicolas Piuzzi, Andrew Zeft, Sirada Panupattanapong, Belinda Willard, Ling Li, Laura Nedorezov, Paul Saluan, Caitlin Lewis, Lutul Farrow
Program leads: Lukas Nystrom, Zachary Burke
The Orthopaedic Oncology Research Program studies primary bone sarcoma, soft tissue sarcoma, metastatic bone disease and benign bone and soft tissue neoplasms. We have a clinical research group, directed by Lukas Nystrom, and a translational science research group, directed by Zachary Burke. We work in a very collaborative environment which spans multiple oncologic specialties including medical and radiation oncology, as well as pathology and radiology. Our aim is to advance the care of patients with these conditions through better understanding of their clinical behavior and clinical outcomes, as well as through understanding their biologic behavior.
Collaborators: Nathan Mesko, Shauna Campbell, Jacob Scott, John Reith, Scott Kilpatrick, Karen Fritchie, Josephine Dermawan, Hakan Ilaslan, Dale Shepard, Joseph Wooley, Matteo Trucco
Program lead: Heather Vallier
The Orthopaedic Trauma Research Program strives to improve our care for people with musculoskeletal injuries. We perform clinical, epidemiological, and outcomes research, routinely collaborating with other institutions in the United States and worldwide. Current interests include factors associated with improved fracture healing, mitigation of risks of complications, and optimization of physical and psychological outcomes following injury. We prospectively collect standardized surveys to assess extremity-specific and generalized musculoskeletal function and to evaluate various aspects of mental health and resilience. We further aspire to better understand the economic impacts of injury and its treatment so that we can enhance trauma care via cost-effectiveness.
Collaborators: Damien Billow, Cesar Cereijo, Anokha Padubidri, Brendan Patterson
Program lead: Megan Jack
The Peripheral Nerve Research Program focuses on a wide spectrum of pathology affecting the peripheral nervous system. Through laboratory and human subjects research, we seek to identify demographic, disease-related, and surgical factors associated with short- and longer-term outcomes following peripheral nerve injury and other pathologies of the peripheral nerve. Our aim is to enhance patient care and outcomes by improving our clinical understanding and optimizing surgical treatments of peripheral nerve injuries, peripheral nerve pain syndromes, spinal cord injury, stroke, and peripheral nerve tumors.
Collaborators: Dennis Kao, Greg Kwiecien
Program lead: Jianguo Cheng
Our research focuses on musculoskeletal pain, emphasizing interventional therapies for myofascial and joint pain in clinical settings. We investigate innovative treatments, including neuroablation, image-guided therapies, and regenerative medicine techniques including stem cell therapy. By analyzing clinical outcomes, we aim to enhance pain management strategies, improve patient quality of life, and provide evidence-based recommendations for practitioners. Our work bridges the gap between emerging therapies and practical, effective clinical applications, striving to offer relief for chronic pain sufferers and advance the field of pain medicine.
Collaborators: Xiaojuan Li, Daniel Rotroff, Jijun Xu
Program lead: George Muschler
Our team focuses on accelerating the rate of development of safe and effective human cell therapies. In particular, we have developed and now use high content imaging and laboratory automation (robotics) as a platform for harvest, isolation, expansion and characterization of human stem and progenitor cells. We currently focus on induced pluripotent stem cells (iPSCs) and mesenchymal stromal cells (MSCs), which may provide high quality starting materials for cell therapy strategies to treat diseases such as arthritis, Parkinson's disease, diabetes, and some causes of blindness.
Collaborators: Kunio Nakamoto, John Barnard, Lekha Swamydas, Nicolas Piuzzi, Xiaojuan Li, Suneel Apte, Ron Midura, Vijay Krishna
Program lead: Paul Marasco
The Neuromuscular Disease Research Program focuses on disorders, degeneration and injury of the nervous system and the musculoskeletal system, and how deficits in one impact operation of the other. Our group explores relationships between the nervous system, muscles, and bones, including sensorimotor control, movement patterns, coordination, dexterity, and pain. Through better understanding of these relationships, we seek to develop interventions and improve diagnosis in a variety of conditions such as Parkinson's disease, multiple sclerosis, concussion, limb loss, diabetes, and cartilage and ligament injuries. We analyze healthy and impaired populations using motion analysis, ultrasound imaging, magnetic resonance imaging, electromyography, electroencephalography, and psychophysical techniques to understand how various conditions affect movement, control, and sensory feedback. Computational modeling helps characterize pathology as well as the influence of surgical and rehabilitation interventions. In addition, we incorporate technologies, such as robotic devices and deep brain stimulation, into treatments and quantify resulting benefits to patient health and quality of life.
Program lead: Ahmet Erdemir and Snehal Chokhandre
Our research program aims to streamline extraction of image- and simulation-based markers for characterization and prediction of knee function. With Open Knee(s), we launched, sustain and are growing a virtual knee cohort to conduct in silico experiments for discovery and innovation. With our multi-site project KNEEHUB, we documented the art of knee modeling and simulation, curated end-to-end simulation approaches, assessed their reproducibility potential, and now establishing community-driven consensus workflows. With Kneeformatics, we invented novel strategies for individualized determination of knee movement capacity and signature solely from static clinical imaging. We aim to use this translational technology for phenotyping of knee mobility, for diagnosis and prognosis of knee pathology, and for surgical planning.
Program lead: Xiaojuan Li, Carl Winalski
The Program of Advanced Musculoskeletal Imaging (PAMI) is built upon Cleveland Clinic's nationally-ranked clinical care and research programs in orthopaedics, rheumatology and imaging. Our mission is to advance musculoskeletal imaging for improved orthopaedic and rheumatologic healthcare through technical development, clinical translation, and education. Novel imaging and image processing techniques are being developed and validated for improved structural, biochemical, and functional assessment of musculoskeletal tissues (cartilage, bone, tendon, ligament, muscle, fat, etc.). PAMI also strives for rapid clinical translation of state-of-the-art imaging techniques into routine clinical use to improve early diagnosis and prognosis for patients with significant musculoskeletal diseases. In addition to technical development, PAMI has a particular emphasis combining quantitative imaging, advanced data analysis methodologies (including big data analysis) and machine learning techniques. PAMI embraces all imaging modalities including MR (3T and 7T), CT, nuclear medicine and ultrasound.
Collaborators: Faysal Altahawi, Charlie Androjna, Po-Hao Chen, Robb Colbrunn, Srinivasan Dasarathy, Chad Deal, Kathleen Derwin, Frank DiFilippo, Brendan Eck, John Elias, Todd Emch, Ahmet Erdemir, Lutul Farrow, Michael Forney, Ghaith Habboub, Stephen Hatem, Darlene Holden, Elaine Husni, Joseph Iannotti, Hakan Ilaslan, Stephen E. Jones, Bong Jae Jun, Atul Kamath, Vladimir Kepe, Aaron Lear, Xiaojuan Li, Mark Lowe, Charles Martin III, Anthony Miniaci, George Muschler, Kunio Nakamura, Nancy Obuchowski, Erik Pioro, Joshua Polster, Eric Ricchetti, Sambit Sahoo, Jean Schils, Wanyong Shin, Claus Simpfendorfer, Kurt Spindler, Michael Steinmetz, Naveen Subhas, Carl Winalski, Mingrui Yang, Stefan Zbyn
Program lead: Robb Colbrunn
The Orthopaedic Biomechanics research program is focused on mechanistic relationships between anatomical structures, surgical interventions, and joint movement & loading patterns. We have developed advanced robotic and mechatronic technologies to assist in answering these types of clinical questions. We study all the major joints including knee, spine, hip, shoulder, elbow, foot/ankle, and hand/wrist. The aim of our translational research program is to guide clinical decision making with a mechanistic understanding of the joint biomechanics of surgical interventions.
Collaborators: Paul Saluan, Mike Steinmetz, Bilal Butt, Lutul Farrow, Mark Schickendantz, Nicolas Piuzzi, Ahmet Erdemir, Viktor Krebs
Program lead: Nicolas Piuzzi, Alison Klika
The vision of the Cleveland Clinic Adult Joint Reconstruction Research (CCARR) Program is to advance personalized patient care through evidence-based orthopedic practice and meaningful research. CCARR focuses on six strategic areas: (1) Personalized total joint arthroplasty (TJA) outcomes; (2) Robotic surgery and technology; (3) Revision TJA; (4) Periprosthetic joint infection (PJI); (5) Joint preservation and orthobiologics; and (6) Basic science/translational research related to Biofilm and PJI. Our program aims to identify key factors affecting outcomes in primary and revision TJA procedures. Through extensive basic, translational, and clinical research, we strive to enhance personalized clinical decision-making, patient and disease phenotyping, and the management of socioeconomic and disease-related factors, used to refine surgical techniques and care pathways. Our research directly translates to clinical practice, focusing on hip and knee procedures for osteoarthritis, osteonecrosis, arthrofibrosis, osteolysis, periprosthetic infections, and fractures. CCARR is committed to advancing personalized medicine, utilizing advanced analytical AI for outcome prediction, and developing programmatic research to innovate and create impactful solutions. Recognized as a world leader in arthroplasty research, the program publishes over 100 peer-reviewed manuscripts annually and conducts more than 10 clinical trials.
Collaborators: Anabelle Visperas, Matthew Deren, Viktor Krebs, Robert Molloy, Michael Bloomfield, John McLaughlin, Trevor Murray, Alexander Roth, Peter Surace, Nicholas Scarcella, Kim Stearns, Carlos Higuera-Rueda, Thaddeus Stappenbeck, Suneel Apte, Weiqiang Chen, Suan Sin Foo
Program lead: Scott Kilpatrick, John Reith
Orthopedic pathology involves both neoplasms and non-neoplastic diseases. For the former, we actively investigate and define clinicopathologic features of existing neoplasms (and variants) and entirely new entities, within the musculoskeletal system. Evaluation of immunohistochemistry and novel molecular characteristics is ongoing. For non-neoplastic diseases, we seek to understand the clinicoradiological and pathological characteristics of the more common orthopedic problems, while also assessing the importance of routine histologic examination among frequently seen orthopedic specimens. Based on our arthroplasty data, establishing an accurate and consistently reliable diagnosis of avascular necrosis, osteoarthritis with secondary osteonecrosis, subchondral insufficiency fracture, and calcium pyrophosphate dihydrate disease (pseudogout) requires pathologic examination, as predisposing clinical features are frequently absent and radiographs often misleading. Current multidisciplinary studies also are evaluating the incidence and significance of amyloid detection in a variety of routine, seemingly insignificant, orthopedic specimens obtained from surgeries related to carpal tunnel, trigger finger, and spinal ligamentum flavum.
Collaborators: Brian Rubin, Steven Billings, Karen Fritchie, Josephine Dermawan, Hakan Ilaslan, John Goldblum, Nate Mesko, Luke Nystrom, Zachary Burke, William Seitz Jr.
Program lead: Xiaojuan Li, Kurt Spindler
The Post-traumatic Osteoarthritis research program focuses on identifying novel 'biomarkers' (risk factors) that provide reliable early diagnosis and prognosis of post-traumatic osteoarthritis (PTOA) development after joint injuries. Our multidisciplinary team investigates cohorts of human subjects as well as laboratory models of PTOA, using clinical and patient-reported outcomes, clinical and advanced quantitative imaging, and biomechanical modeling. Conventional multivariate analysis as well as machine learning techniques are used to build models that predict long-term outcomes after injury and non-surgical or surgical interventions. By identifying modifiable predictors of PTOA development after joint injuries or surgery, our goals are to provide guidance for future development of novel interventions to reduce and prevent PTOA, help clinicians stratify subjects with regard to their individual risk of developing PTOA and improve clinical care in a directed and evidence-based way for this young and active population.
Collaborators: Faysal Altahawi, Suneel Apte, Gerald Beck, Jianguo Cheng, Robb Colbrunn, Brendan Eck, John Elias, Ahmet Erdemir, Lutul Farrow, Jason Genin, Peter Imrey, Bong Jae Jun, Atul Kamath, George Muschler, Nancy Obuchowski, Richard Parker, Dominic Pelle, Joshua Polster, Naveen Subhas, Carl Winalski, Mingrui Yang, Stefan Zbyn
NIH (NINDS) — R01NS073717
Alberts, Jay
“The Cyclical Lower-Extremity Exercise (CYCLE) for Parkinson’s Trial”
NIH (NIAMS) — R01AR068342
Derwin, Kathleen / Iannotti, Joseph
“Failure with Continuity and its Relation to Rotator Cuff Repair Clinical Outcomes”
NIH (NIAMS) — R01AR077452
Li, Xiaojuan
“Multi-Vendor Multi-Site Novel Accelerated MRI Relaxometry”
NIH (NIAMS) — R01AR074131
Spindler, Kurt
“BEAR-MOON: A Two Arm Noninferiority Blinded Randomized Clinical Trial Comparing ACL Repair with BEAR Device vs. Standard of Care Autograft Patellar Tendon ACL Reconstruction”
NIH (NIAMS) — R01AR075422
Li, Xiaojuan
“Imaging post-traumatic osteoarthritis 10-years after ACL reconstruction: a multicenter cohort study with quantitative MRI”
NIH (NICHD) — K01HD092556
Linder, Susan
“Cost-effectiveness and efficacy of a combined intervention to facilitate motor recovery following stroke”
NIH (NIAMS) — R21AR078401
Derwin, Kathleen
“Variation in Humeral Head Bone Marrow Characteristics and Their Associations with Rotator Cuff Repair Healing”
NIH (NIAMS) — R01AR055557 (sub-award)
Spindler, Kurt
“Partial Meniscectomy versus Nonoperative Management in Meniscal Tear with OA: An RCT”
NIH (NINDS) — U01NS113851 (sub-award)
Alberts, Jay
“Study in Parkinson Disease of Exercise Phase 3 Clinical Trial: SPARX3”
NIH (NIAMS) — U01AR080377 (sub-award)
Piuzzi, Nicolas
“HIP ATTACK-2 trial (HIP fracture Accelerated surgical care and TreaTment trACK) 2”
$10.4 Million
Total Grant Funding (2022)
NIH (NCCIH) — R01AT011905
Marasco, Paul
“Sensing active movement of the self: reconsidering the cellular basis kinesthesia”
NIH (NIAMS) — R01AR073225
Streubel, Philipp
“3D bioprinting of biomimetic constructs for rotator cuff augmentation”
NIH (NIBIB) — R01EB025212
Erdemir, Ahmet
"Software for Practical Annotation and Exchange of Virtual Anatomy"
NIH (NIDCR) — R01DE029634
Muschler, George
"Understanding and Using Variation in Source Materials for MSC Fabrication"
NIH (NIAMS) — R01AR077452
Li, Xiaojuan
"Multi-Vendor Multi-Site Novel Accelerated MRI Relaxometry"
NIH (NIAMS) — R01AR075422
Li, Xiaojuan
"Imaging post-traumatic osteoarthritis 10-years after ACL reconstruction: a multicenter cohort study with quantitative MRI"
NIH (NIAMS) — R01AR068342
Derwin, Kathleen / Iannotti, Joseph
"Failure with Continuity and its Relation to Rotator Cuff Repair Clinical Outcomes"
NIH (NINDS) — R01NS073717
Alberts, Jay
"CYClical Lower Extremity exercise for Parkinsons trial (CYCLE Trial)"
NIH (NIAMS) — R01AR074131
Spindler, Kurt
"BEAR-MOON: A Two Arm Noninferiority Blinded Randomized Clinical Trial Comparing ACL Repair with BEAR Device vs. Standard of Care Autograft Patellar Tendon ACL Reconstruction"
NIH (NIAMS) — R01AR075286
Ricchetti, Eric
"Identifying the Patient, Disease, Surgical, and Implant Positional Shift Factors that Predict Outcomes Following Total Shoulder Arthroplasty"
NIH (NIAMS) — R13AR076258
Spindler, Kurt
"Clinician Scholar Career Development Program (CSCDP)"
NIH (NIAMS) — R21AR078498
Apte, Suneel
“The proteolytic landscape of osteoarthritic cartilage”
NIH (NIAMS) — R21AR078401
Derwin, Kathleen
“Variation in Humeral Head Bone Marrow Characteristics and Their Associations with Rotator Cuff Repair Healing”
NIH (NINDS) — R21NS129147
Alberts, Jay
“The impact of exercise on subthalamic nucleus neural activity in Parkinson's disease”
NIH (NICHD) — K01HD092556
Linder, Susan
“Cost-effectiveness and efficacy of a combined intervention to facilitate motor recovery following stroke”
NIH (NIAMS) — K25AR078928
Yang, Mingrui
“Automated Arthroscopic Partial Meniscectomy Patient Outcome Prediction using Deep Learning”
NIH (NIAMS) — R01AR055557 (sub-award)
Spindler, Kurt
“Partial Meniscectomy vs. NonOperative Management in Meniscal Tear with OA: An RCT”
NIH (NIAMS) — U01AR080377 (sub-award)
Piuzzi, Nicolas
“HIP ATTACK-2 trial (HIP fracture Accelerated surgical care and TreaTment trACK) 2”
NIH (NINDS) — U01NS113851 (sub-award)
Alberts, Jay
"Study in Parkinson Disease of Exercise Phase 3 Clinical Trial: SPARX3"
| 2015–2020 | 2021 | 2022 | 2023 | Cumulative | |
|---|---|---|---|---|---|
| Invention disclosures | 98 | 17 | 24 | 14 | 153 |
| Patent applications | 72 | 10 | 13 | 14 | 109 |
| Patents granted | 108 | 15 | 3 | 11 | 137 |
Muschler GF, Monnich JK, Kwee EJ, Powell KA, Herderick EE, Boehm CA, Adams TR, Germanoski R, Krakosh III F, Dunn J, Bantz D: "Systems and methods for detection, analysis, isolation and/or harvesting of biological objects". US Patent No: 11,579,160; granted Feb 2023.
McCrae K, Merkulov S, Alluri RK: "Human β2-glycoprotein I expression". US Patent No: 11,661,447; granted May 2023.
Colbrunn R, Nagle T, Gillespie C: "Hybrid control of a robotic system". US Patent No: 11,691,280; granted Jul 2023.
Iannotti JP, Barsoum WK, Bryan JA, O'Neill PD: "System and method for association of a guiding aid with a patient tissue". US Patent No: 11,730,497; granted Aug 2023.
Gillespie C, Colbrunn R, Nagle T: "Compliance correction in a robotic system". US Patent No: 11,745,341; granted Sep 2023.
Assell R, Freeman A, Muschler G: "Bone void filler preparation system". US Patent No: 11,850,326; granted Dec 2023.
Assell R, Freeman A, Muschler GF: “Bone fragment and tissue harvesting system”. US Patent No: 11,337,710; granted May 2022.
Baker JJ, Gingras PH, Priest R, Derwin K, Iannotti JP, Sahoo S, Baker AR: “Radiopaque tissue marker”. US Patent No: 11,413,112; granted Aug 2022.
Schoenhagen P, Chen PH, Piraino D, Obuchowski N: “Automated identification of acute aortic syndromes in computed tomography images”. US Patent No: 11,475,561; granted Oct 2022.
Assell R, Freeman A, Muschler G: “Bone void filler preparation system”. US Patent No: 10,953,134; granted Mar 2021.
Iannotti JP, Barsoum WK, Bryan JA, O’Neill PD: “System of preoperative planning and provision of patient-specific surgical aids”. US Patent No: 10,973,535; granted Apr 2021.
Derwin KA, Iannotti JP, Sahoo S: “Reinforced tissue graft”. US Patent No: 11,013,590; granted May 2021.
Muschler GF, Monnich JK, Kwee EJ, Powell KA, Herderick EE, Boehm CA, Adams TR, Germanoski R, Krakosh III F, Dunn J, Bantz D: “Systems and methods for detection, analysis, isolation and/or harvesting of biological objects”. US Patent No: 10,564,172; granted Feb 2020.
Schindler DD, Alberts JL, Hirsch JR: “Systems and Methods to Assess Balance and Stability”. US Patent No: 10,588,546; granted Mar 2020.
Iannotti JP, Barsoum WK, Bryan JA, O’Neill PD: “System and Method for Association of a Guiding Aid with a Patient Tissue”. US Patent No: 10,624,655; granted Apr 2020.
Assell R, Freeman A, Muschler GF: “Bone Fragment and Tissue Harvesting System”. US Patent No: 10,610,242; granted Apr 2020.
Alberts JL, Bermel R, Rao S, Schlinder DD: “Assessment of Low Contrast Visual Sensitivity”. US Patent No: 10,667,682; granted Jun 2020.
Alberts JL, McIntyre C: “System and Method for Motor and Cognitive Analysis”. US Patent No: 10,741,287; granted Aug 2020.
Derwin K, Aurora A, Iannotti JP, McCarron, JA: “Reinforced Tissue Graft”. US Patent No: 10,758,644; granted Sep 2020.
Cheng J: “Devices and Methods for Treating Medical Conditions Associated with Sacroiliac Joint Abnormalities”. US Patent No: 10,849,708; granted Dec 2020.
Alberts JL, Schindler DD: “Object Recognition by Touch Screen”. US Patent No: 10,206,609; granted Feb 2019.
Iannotti JP, Barsoum WK, Bryan JA: “System and Method for Assisting with Attachment of a Stock Implant to a Patient Tissue”. US Patent No: 10,258,352; granted Apr 2019.
Iannotti JP, Barsoum WK, Bryan JA: “Apparatus and Method for Providing a Reference Indication to a Patient Tissue”. US Patent No: 10,307,174; granted Jun 2019.
Assell R, Freeman A, Muschler G: “Bone Fragment and Tissue Processing System”. US Patent No: 10,342,552; granted Jul 2019.
Derwin KA, Iannotti JP, Milks RA: “Devices and Methods for Tissue Graft Delivery”. US Patent No: 10,383,657; granted Aug 2019.
Alberts JL, Schindler DD, Rhodes J, Gabel W, Best J: “Apparatus and Related Method to Facilitate Testing Via a Computing Device”. US Patent No: 10,420,497; granted Sep 2019.
Iannotti JP, Barsoum WK, Bryan JA, O’Neill P: “Alignment of Manipulable Sensor Assembly”. US Patent No: 10,456,062; granted Oct 2019.
Assell R, Freeman A, Muschler G: “Bone Void Filler Preparation System”. US Patent No: 10,456,502; granted Oct 2019.
Alberts JL, Rudick RA, Schindler DD, Hirsch J, Rao SM, Bethoux F, Linder S, Miller D: “Performance Test for Evaluation of Neurological Function”. US Patent No: 10,470,679; granted Nov 2019.
Iannotti JP, Barsoum WK, Bryan JA: “System and Method for Assisting with Arrangement of a Stock Instrument with Respect to a Patient Tissue”. US Patent No: 10,512,496; granted Dec 2019.
Alberts JL, Bermel R, Rao S, Schindler DD: “Assessment of Low Contrast Visual Sensitivity”. US Patent No: 10,028,653; granted Jul 2018.
Derwin KA, Calabro A: “Biocompatible Tissue Graft”. US Patent No: 10,004,586; granted Jun 2018.
Evans PJ, Trickett J: “Multipurpose Membranes, Methods for Forming, and Applications Thereof”. US Patent No: 10,086,110; granted Oct 2018.
Iannotti JP, Barsoum WK, Bryan JA: “System and Method for Assisting with Attachment of a Stock Implant to a Patient Tissue”. US Patent No: 9,877,735; granted Jan 2018.
Machado AG, Alberts JL, McIntyre C, Schindler DD: “Evaluation of Movement Disorders”. US Patent No: 10,028,695; granted Jul 2018.
Alberts JL: “System and Method to Facilitate Analysis of Brain Injuries and Disorders”. US Patent No: 9,610,029; granted Apr 2017.
Alberts JL, McIntyre CC: “Reversing Cognitive-Motor Impairments in Patients Having a Neuro-Degenerative Disease Using a Computational Modeling Approach to Deep Brain Stimulation Programming”. US Patent No: 9,776,003; granted Oct 2017.
Alberts JL, McIntyre CC: “System and Method for Motor and Cognitive Analysis”. US Patent No: 9,653,002; granted May 2017.
Alberts JL, Schindler DD: “Object Recognition by Touch Screen”. US Patent No: 9,737,242; granted Aug 2017.
Iannotti JP: “Prosthetic Articulation Surface Mounting”. US Patent No: 9,572,670; granted Feb 2017.
Iannotti JP, Barsoum WK, Bryan JA, O’Neill PD: “System of Preoperative Planning and Provision of Patient-Specific Surgical Aids”. US Patent No: 9,741,263; granted Aug 2017.
Iannotti JP, Barsoum WK, Bryan JA, O’Neill PD: “System of Preoperative Planning and Provision of Patient-Specific Surgical Aids”. US Patent No: 9,717,508; granted Aug 2017.
Iannotti JP, Barsoum WK, Bryan JA, O’Neill PD: “System and Method for Association of a Guiding Aid with a Patient Tissue”. US Patent No: 9,615,840; granted Apr 2017.
Polster JM, Hoffman G: “Tissue Sampling Device”. US Patent No: 9,622,727; granted Apr 2017.
Derwin KA, Iannotti JP, Milks RA: “Devices and Methods for Tissue Graft Delivery“. US Patent No: 9,265,524; granted Feb 2016.
Iannotti JP: “Humeral Joint Replacement Component”. US Patent No: 9,512,445; granted Dec 2016.
Iannotti JP: “Prosthetic Articulation Surface Mounting”. US Patent No: 9,241,804; granted Jan 2016.
Iannotti JP, Barsoum WK, Bryan JA: “Apparatus and Method for Providing a Reference Indication to a Patient Tissue”. US Patent No: 9,326,781; granted May 2016.
Iannotti JP, Barsoum WK, Bryan JA: “System and Method for Assisting with Arrangement of a Stock Instrument with Respect to a Patient Tissue”. US Patent No: 9,254,155; granted Feb 2016.
Iannotti JP, Bonutti PM: “Methods and Devices for Bone Preparation”. US Patent No: 9,439,704; granted Sep 2016.
Iannotti JP, Williams G, Koka D, Hollis MC: “Glenoid Vault Fixation”. US Patent No: 9,439,768; granted Sep 2016.
Iannotti J, Williams G, Koka D, Hollis MC: “Shoulder Arthroplasty”. US Patent No: 9,414,927; granted Aug 2016.
Miniaci A, Fening SD, Hartzell BE: “Apparatus and Method for Sequentially Anchoring Multiple Graft Ligaments in a Bone Tunnel”. US Patent No: 9,339,370; granted May 2016.
Polster J: “Percutaneous Needle Guide and Method”. US Patent No: 9,381,035; granted Jul 2016.
Polster JM: “Method and Apparatus for Tissue Sampling”. US Patent No: 9,326,754; granted May 2016.
Alberts JL: “Systems and Methods for Improving Motor Function with Assisted Exercise”. US Patent No: 9,067,098; granted Jun 2015.
Fening SD, Miniaci A: “Apparatus and Method for Sequentially Anchoring Multiple Graft Ligaments in a Bone Tunnel”. US Patent No: 9,011,536; granted Apr 2015.
Iannotti JP, Barsoum WK, Bryan JA: “Apparatus and Method for Dictating at Least One of a Desired Location and a Desired Trajectory for Association of a Landmark with a Patient Tissue”. US Patent No: 9,198,732; granted Dec 2015.
Iannotti JP, Barsoum WK, Bryan JA: “Directed Structure Placement Guide”. US Patent No: 9,033,990; granted May 2015.
Iannotti JP, Barsoum WK, Bryan JA: “Positioning Apparatus and Method for a Prosthetic Implant”. US Patent No: 9,011,452; granted Apr 2015.
Iannotti JP, Barsoum WK, Bryan JA: “Apparatus and Method for Providing a Reference Indication to a Patient Tissue”. US Patent No: 8,992,539; granted Mar 2015.
Iannotti JP, Barsoum WK, Bryan JA: “Apparatus and Method for Transferring Predetermined Spatial Positioning Information to an Adjustable Tool”. US Patent No: 8,926,627; granted Jan 2015.
Iannotti JP, Bonutti PM: “Methods and Devices for Bone Preparation”. US Patent No: 9,216,046; granted Dec 2015.
Machado A, Alberts JL, McIntyre C, Schindler D: “Evaluation of Movement Disorders”. US Patent No: 9,186,095; granted Nov 2015.
Muschler G, Caralla T, Hascall V, Midura R: “Enrichment of Tissue-Derived Adult Stem Cells Based on Retained Extracellular Matrix Material”. US Patent No: 9,045,735; granted Jun 2015.
Polster JM: “Augmented Reconstruction for Computed Tomography”. US Patent No: 9,153,045; granted Oct 2015.
The Musculoskeletal Research Center's Pilot Project Program for Cleveland Clinic investigators is available to support currently unfunded, novel, particularly innovative, disease-oriented projects that are in need of the early data that would make them competitive for extramural funding. Funding will be available to support projects along the entire continuum of biomedical investigation, including discovery, translation and direct patient-involved research.
Two types of awards of up to $25,000 each are available: (1) MSRC General awards are for musculoskeletal research projects on any topic related to musculoskeletal research, and (2) MSRC MSK Imaging awards are for musculoskeletal imaging research projects. Announcement of funding opportunity will be made to MSRC members via email.
InfoReady Review is used to manage Pilot Project submissions. Each competition will be launched on the InfoReady Review home page one month prior to the deadline. If you have any issues submitting an application, please contact us.
The Amy and David Krohn Family Orthopaedic Outcomes Center (OOC) is an arm of the Cleveland Clinic Musculoskeletal Research Center (MSRC) focusing primarily on the clinical outcomes of orthopaedic surgery and related treatments. Bringing together the expertise of orthopaedic clinicians, researchers, data scientists, and statisticians, the OOC endeavors to:
Members
Overview
The OOC's flagship service is the Outcomes Management and Evaluation (OME) system, which is used across the institution to systematically collect patient-reported outcome measures (PROMs) in a highly structured and consistent manner. OME is a cost-effective, scientifically valid, scalable electronic system for collecting PROMs and clinical information surrounding an episode of care:
Initially launched in 2015 an "Episode of Care" supplement to the OOC's former OrthoMiDaS system, OME has since supplanted OrthoMiDaS to establish itself as the de-facto data collection mechanism for orthopaedic surgery. The data collected through this system feeds the OME Cohort, a powerful prospective cohort that supports standard of care, quality initiatives, and three primary points of research focus:
Current Enrollment
As of August 2019, OME is active at 16 Cleveland Clinic hospitals and ASCs and covers over 95% of elective orthopaedic surgery cases performed on the knee, hip, and shoulder, ranging from arthroscopy to arthroplasty. OME is also used in select spine, hand, wrist, foot, and ankle surgeries, as well as for patients receiving non-surgical orthobiologic treatment and patients undergoing MRI scans for sports injuries. Over 45,000 episodes of care representing over 40,000 patients have been collected to date with average baseline PROM completion rates of over 95% and 1-year follow-up PROM completion rates of over 70%. Additional orthopaedic and non-orthopaedic procedures are being added to the OME portfolio regularly.
Publication Tracker (FINER Form)
BEAR-MOON
Multicenter FDA trial funded by NIH/NIAMS comparing the BEAR® scaffold for ACL repair to standard of care ACL reconstruction
https://bearmoon.org
MSRC Steering Committee
Lerner Research Institute
Surgical Specialty
Diagnostic Services
Medical Specialty
Neurosciences
Children's Services
Hospital Based Care
Digestive Disease