Welcome to the Cleveland Clinic risk assessment tool for estimation of a person's risk of having a PTEN mutation. Clinical syndromes often associated with this gene mutation include Cowden syndrome (CS) and Bannayan-Riley-Ruvalcaba syndrome (BRRS). This tool was designed for use by healthcare professionals. If you are not a healthcare professional, you are encouraged to discuss the results with your doctor or a genetics healthcare provider. Detailed information on the Cleveland Clinic adult score and pediatric criteria is available.