Scott Cameron, PhD, MD, RPVI
Associate Staff
Staff Cardiologist
Location: Cleveland Clinic Main Campus
Research
I treat patients with thrombi (blood clots) in the heart, the brain, the lung, and the legs. Small particles in the blood called platelets start the process of forming blood clots. My laboratory discovered that platelets become reprogrammed in diseases such as heart attack and peripheral artery disease. When platelets are reprogrammed, they do not respond as predicted to medications. Platelets can also be considered as circulating messengers, carrying information back and forth between blood vessels and organs in the body. A major goal of my research is to understand the process of platelet reprogramming, and to identify additional proteins on platelets which could be targets for new medications.
Biography
Scott Cameron, MD, PhD, is Section Head, Vascular Medicine in the Tomsich Family Department of Cardiovascular Medicine, Sydell and Arnold Miller Family Heart, Vascular & Thoracic Institute. He is a specialist in blood vessel disorders and platelet dysfunction and sees patients at Cleveland Clinic main campus.
Dr. Cameron currently is the Principal Investigator (PI) on National Institutes of Health-funded studies since 2015 on cardiovascular complications that develop after heart attack and also on aortic aneurysmal disease and dysregulated platelet function. He has been PI or co-PI on multiple basic, translational and clinical research studies on heart attack, arterial disease, aneurysms, pulmonary embolism and COVID-19-related thrombosis. Dr. Cameron has co-authored more than 70 scientific papers and editorials in peer-reviewed medical journals on platelet disorders and vascular medicine and has been an invited lecturer at numerous international and national medical meetings and conferences. He is also on the American Board of Internal Medicine question committee for Cardiovascular Disease.
Dr. Cameron is also a Fellow of the American College of Cardiology and the Society of Vascular Medicine. He sits on various counsels of the American Heart Association. He is a frequent peer reviewer for multiple medical journals including the British Medical Journal, the American Journal of Medicine, Annals of Internal Medicine, Circulation, Circulation Research, JACC, the Journal of Clinical Investigation, and the Journal of Thrombosis and Thrombolysis. He is also on the Editorial Board of ATVB, and he is an Associate Editor of Vascular Medicine.
Education & Professional Highlights
Education & Fellowships
Fellowship - Strong Memorial Hospital of The University of Rochester
Cardiovascular Disease and Vascular Medicine
Rochester, NY USA
2016
Residency - New York Presbyterian Hospital
Medicine
New York, NY USA
2011
Medical Education - State University of New York (SUNY) Upstate Medical University
Medicine
Syracuse, NY USA
2009
Fellowship - Johns Hopkins Hospital
Chemical Pathology/Clinical Chemistry
Baltimore, MD USA
2005
Graduate School - University of Rochester Medical Center
Pharmacology
Rochester, NY USA
2003
Unergraduate - University of Edinburgh
Pharmacology
Edinburgh, Scotland, UK
1998
Additional Training
- COCATS Level II Competence in Adult Comprehensive Echocardiography
- COCATS Level II Competence in Nuclear Cardiology
- Clinical Chemistry (Chemical Pathology)
Professional Highlights
- Founding Member and Director, University of Rochester Pulmonary Embolism Response Team: Award from the Hospital Board on Quality and Safety in Patient Care.
Certifications
- National Board of Medical Examiners - General Medicine
- American Board of Internal Medicine - Internal Medicine (voluntary recertification)
- American Board of Internal Medicine - Cardiovascular Disease
- American Board of Vascular Medicine - General Vascular Medicine
- Alliance for Physician Certification & Advancement - Registered Physician in Vascular Interpretation
Awards & Honors
- 2024 Best Doctors List (Cardiology, Vascscular Medicine), Cleveland Clinic Magazine
- 2024 Marquis Who's Who in America
- 2022 Gill Heart and Vascular Institute Early Career Award
- 2019 Outstanding Young Alumnus Award in 20 years, Upstate Medical University
- 2017 Quality and Safety Certificate - Pulmonary Embolism Response Team
- 2016 Fellow of the American College of Cardiology
- 2016 Fellow of the Society of Vascular Medicine
- 2015 Platelet Colloquium Career Investigator Award, University of Kentucky
- 2014 CVRI Scientific Advisory Board Postdoctoral Research Award (first place)
- 2012 Multiple “Strong Star” nominations from patients and colleagues for exceptional clinical care
- 2009 Alpha Omega Alpha Research Award
- 2009 Herbert Lourie, MD Graduation Award
- 2008 Gold Humanism Honor Society
- 2005 Paul E. Standjord Young Investigator’s Award - with distinction
- 2005 Pathology Young Investigator’s Award for excellence in basic research
- 2004 Pathology Young Investigator’s Award for excellence in clinical research
- 2003 Dean's Award for the most innovative PhD Thesis
Memberships
- Fellow, American College of Cardiology
- Fellow, Society of Vascular Medicine
- Member, American Heart Association
- Member, International Society of Thrombosis and Haemostasis
Research
We are a basic and translational research laboratory that studies the adaptive platelet phenotype in vascular and thrombotic disorders. Platelets are small anucleate blood particles which play an important role in thrombosis, hemostasis, and inflammation.
Our laboratory was the first to identify that platelets are reprogrammed from their native, healthy state to a dysregulated state in the circulation at the time of acute myocardial infarction. We have since demonstrated that the anucleate platelet is sensitive to its external environment in vivo and ex vivo, and capable of altering post-receptor signal transduction events. This changes the response of platelets to anti-platelet medications. Current and recent work has focused on sex-dependent differences in vascular and thrombotic diseases, bidirectional communication between blood vessels and platelets, and capitalizing on platelets as circulating biosensors to better understand diseases.
Our primary observations are made in humans and in privileged human tissue accessible through our academic clinical practice. An advantage of this approach is that it assures translatibility since many mechanistic studies in animals do not translate into a human therapeutic intervention. We create murine models of diseases to further explore mechanisms and use a variety of molecular, biochemical, and cellular assays for a comprehensive and mechanistic investigation.
Diseases we study: aneurysmal disease, aortic rupture, venous insufficiency, pulmonary embolism, deep vein thrombosis, SARS-CoV-2, Post-Acute Sequelae of COVID-19; rare vascular and metabolic disorders (fibromuscular dysplasia, spontaneous coronary artery dissection, Klippel-Trenaunay Syndrome, lipedema).
Disease mechanisms we study: acute and chronic alterations in the circulating platelet phenotype, platelet-mediated remodeling of distant vascular and cardiac tissue, sex-dependent differences in aneurysmal disease, sex-dependent differences in platelet responses to medications, biomechanical platelet activation, signal transduction, utilization of platelets as circulating biosensors, thrombus resolution, outcomes in thrombotic and vascular diseases, protein kinases and signal transduction, proteomics.
Biomedical focus: pharmacology, biochemistry, vascular medicine, cardiology, platelet function, thrombosis, clinical chemistry, biomarker discovery, 'omics, cell signaling.
We are a friendly, collaborative laboratory with a keen interest in the happiness and career development of all laboratory members. We celebrate each lab member's professional as well as personal success. We collaborate widely, and choose our collaborators carefully. Several Cameron lab alumni have been accepted to top tier Ph.D. programs and M.D. programs over the last 4 years. Our training environment is particularly well-suited for aspiring physician scientists. A position is available for a highly motivated M.D./Ph.D. student.
A Sample of Recent Lab Alumni and Next Position
Suman Guntupalli: MD/MS Student, Cleveland Clinic Lerner College of Medicine
Reina Samuel: MD Student, Case Western Reserve University School of Medicine
Dr. Esssa Hariri: Cardiology Fellow, Johns Hopkins Hospital
Muzammil Arif Din Abdul Jabbar: MBBChir/PhD Student, University of Cambridge
Matthew Godwin: PhD Student, Cleveland Clinic Lerner College of Medicine
Courtney Jennings: PhD Student, Cleveland Clinic Lerner College of Medicine
Dr. Muhammad Umar Khalid: Cardiology Fellow, Rochester Regional Health
Annelise Hamer, MD Student, SUNY Upstate Medical University
Dr. Jean-Pierre Iskandar: Cardiology Fellow, University of Rochester
Michael Pham: MD Student, Loyola University Chicago
Crystal Pascual: MD Student, Rush Medical College
Akiirayii Ademoyo: MD Student, Emory University
Dr. Sharon Shim: Vascular Surgery Resident, Northwestern University
Dr. Colin Wright: Interventional Cardiologist, Private Practice
Dr. Doran Mix: Vascular Surgery Attending, University of Rochester
Dr. Ayman Elbadawi: Structural and Interventional Cardiologist, Christus Trinity Clinic
Dr. Sandra Cole, Vascular Surgery Attending, Private Practice
Dr. Beom-Soo Kim: Cardiology Fellow, Northwell Health
Our Team
Selected Publications
Publications in 2024
Thrombophilia Evaluation. Bhalla J, Bishop GJ, Cameron SJ. In Press 2024, Cleveland Clinic Journal of Medicine.
Cellular and Enzymatic Features of Thrombi in Humans Are Vascular Bed-Dependent. Bender MT, Aggarwal A, Godwin M, Guntupalli S, Nanjundappa A, Tefera L, Haddadin I, Tong M, Baldwin WM, Fairchild RL, Gomes M, Campbell J, Schumick D, Chaudhury P, Mix D, Cameron SJ. In Press 2024, Blood-VTH.
Chaudhary R, Smith JNP, Tiwari R, Klein BR, Cordova BA, Petroze F, Richardson B, Broncano AV, Lee J, Parthasarathy PB, De Carvalho KIL, Cameron SJ, Lathia JD, Goodman WA, Cameron MJ, Desai AB. Sex-dependent niche responses modulate steady-state and regenerative hematopoiesis. Exp Hematol. 2024 Jun 6;137:104247. doi: 10.1016/j.exphem.2024.104247. Epub ahead of print. PMID: 38848877.
Benson TW, Pike MM, Spuzzillo AR, Hicks SM, Pham M, Mix DS, Brunner S, Wadding-Lee CA, Conrad KA, Russell HM, Jennings CL, Coughlin TM, Aggarwal A, Lyden SP, Mani K, Bjorck M, Wanhainen A, Bhandari R, Lipworth L, Robinson-Cohen C, Caputo FJ, Shim S, Quesada O, Tourdot B, Edwards TL, Tranter M, Gardiner EE, Mackman N, Cameron SJ, Owens Iii AP. Soluble Glycoprotein VI Predicts Abdominal Aortic Aneurysm Growth Rate and is a Novel Therapeutic Target. Blood. 2024 Jun 20:blood.2023021655. doi: 10.1182/blood.2023021655. Epub ahead of print. PMID: 38900973.
Scalise A, Aggarwal A, Sangwan N, Hamer A, Guntupalli S, Park HE, Aleman JO, Cameron SJ. A Divergent Platelet Transcriptome in Patients with Lipedema and Lymphedema, Genes 2024 Jun 4;15(6):737. doi: 10.3390/genes15060737. PMID: 38927673.
Smith JNP, Cordova BA, Richardson B, Christo KF, Campanelli J, Broncano AV, Chen J, Lee J,. Cameron SJ, Lathia JD, Goodman WA, Cameron MJ, Desai A. Sex-specific niche signaling contributes to sexual dimorphism following stem cell transplantation. Experimental Hematology, In Press.
Alkhalfan F, Bukhari S, Rosenzveig A, Moudgal R, Khan SZ, Ghoweba M, Chaudhury P, Cameron SJ, Tefera L. The Obesity Mortality Paradox in Patients with Pulmonary Embolism: Insights from a Tertiary Care Center. J Clin Med. 2024 Apr 19;13(8):2375. doi: 10.3390/jcm13082375. PMID: 38673648; PMCID: PMC11051153.2.
Din Abdul Jabbar MA, Bishop GJ, Raja S, Tong MZ, Cameron SJ. Pulmonary Sarcoma: a wolf in sheep's clothing. Am J Med. 2024 Jan 31:S0002-9343(24)00048-2. doi: 10.1016/j.amjmed.2023.12.029. Epub ahead of print. PMID: 38307151.
Khalid MU, Prasada S, Jennings C, Bartholomew JR, McCarthy M, Hornacek DA, Joseph D, Chen W, Schwarz G, Bhandari R, Elbadawi A, Cameron SJ. Venous thromboembolic outcomes in patients with lymphedema and lipedema: An analysis from the National Inpatient Sample. Vasc Med. 2024 Feb;29(1):42-47. doi: 10.1177/1358863X231219006. PMID: 38334096.
Aggarwal A, Singh TK, Pham M, Godwin M, Chen R, McIntyre TM, Scalise A, Chung MK, Jennings C, Ali M, Park H, Englund K, Khorana AA, Svensson LG, Kapadia S, McCrae KR, Cameron SJ. Dysregulated platelet function in patients with postacute sequelae of COVID-19. Vasc Med. 2024 Feb 9:1358863X231224383. doi: 10.1177/1358863X231224383. Epub ahead of print. PMID: 38334067.
Select Publications in 2023
Puthenpura M, Alkhalfan F, Fatima AF, Rajaseka R, Akintoye E, Fendrikova-Mahlay N, Harb S, Cameron SJ, Popovi Z, Chaudhury P. Carotid Duplex Ultrasonography to Assess Severity of Low-Flow Low-Gradient Aortic Stenosis. Am J Med. 2024 Apr;137(4):366-369. doi: 10.1016/j.amjmed.2023.12.005. Epub 2023 Dec 16. PMID: 38110065.Tefera L, Ziada KM, Cameron SJ. Pulmonary Embolism Unplugged: Catheter-Directed Therapies for Intermediate-Risk Pulmonary Embolism. JACC Cardiovasc Interv. 2023 Sep 27:S1936-8798(23)01212-8. doi: 10.1016/j.jcin.2023.08.029. PMID: 37855803.
Tefera L, Cameron SJ, Rajasekar B, Chaudhury P. Pulmonary Embolism Treatment Evolution: A Comparative Analysis of Pulmonary Embolism Response Team Management at a Single Institution. Am J Cardiol. 2023 Oct 14;208:171-172. doi: 10.1016/j.amjcard.2023.09.003. Epub ahead of print. PMID: 37844520.
Kulkarni PP, Alluri RK, Godwin M, Forbes GL, Merkulova A, Vijay A, Palihati M, Kundu S, Jun-Shim Y, Schmaier A, Holinstat M, Cameron SJ, McCrae KR. Protection of β2GPI Deficient Mice from Thrombosis Reflects a Defect in PAR3-facilitated Platelet Activation. bioRxiv [Preprint]. 2023 Aug 24:2023.08.23.554547. doi: 10.1101/2023.08.23.554547. PMID: 37662286; PMCID: PMC10473722.
Abumoawad A, Shatla I, Behrooz L, Eberhardt RT, Hamburg N, Sedhom R, Elgendy IY, Kumbhani DJ, Cameron SJ, Elbadawi A. Temporal Trends in the Utilization of Advanced Therapies Among Patients with Acute Pulmonary Embolism: Insights from a National Database. Eur Heart J Acute Cardiovasc Care. 2023 Aug 7:zuad092. doi: 10.1093/ehjacc/zuad092. Epub ahead of print. PMID: 37549064.
Benson TW, Pike MM, Spuzzillo A, Hicks SM, Pham M, Mix DS, Brunner SI, Wadding-Lee C, Conrad KA, Russell HM, Jennings C, Coughlin TM, Aggarwal A, Lyden S, Mani K, Björck M, Wanhainen A, Bhandari R, Lipworth-Elliot L, Robinson-Cohen C, Caputo FJ, Shim S, Edwards TL, Tranter M, Gardiner EE, Mackman N, Cameron SJ, Owens AP. Glycoprotein VI is Critical for the Detection and Progression of Abdominal Aortic Aneurysms. bioRxiv [Preprint]. 2023 Jul 3:2023.07.02.547361. doi: 10.1101/2023.07.02.547361. PMID: 37461445; PMCID: PMC10349971.
Sheng CC, Wilkoff BL, Lyden SP, Soltesz E, Cameron SJ, Nanjundappa A. Images in Vascular Medicine: Valsalva purpura secondary to balloon occlusion of the cavoatrial junction during intervention for lead-induced SVC syndrome. Vasc Med. 2023 Aug 31:1358863X231191902. doi: 10.1177/1358863X231191902. Epub ahead of print. PMID: 37650456.
Pasha P, Mix D, Eltemamy M, Fendrikova-Mahlay N, Cameron SJ. Saved From Permanent Expulsion: Renal Autotransplant for Aneurysmal Disease. Am J Med. 2023 Jul 13:S0002-9343(23)00436-9. doi: 10.1016/j.amjmed.2023.06.022. Epub ahead of print. PMID: 37451391.
Ali A, Dang AT, Cameron SJ, Banerjee S, Mamas M, Kumbhani DJ, Elgendy IY, Elbadawi A. Extracorporeal Cardiopulmonary Resuscitation for Refractory Out-of-Hospital Cardiac Arrest: A Meta-Analysis of Randomized Trials. JACC Cardiovasc Interv. 2023 Jun 7:S1936-8798(23)00856-7. doi: 10.1016/j.jcin.2023.05.025. Epub ahead of print. PMID: 37354163.Cameron SJ, Carman TL. Thromboprophylaxis for COVID-19: Time to ask for an extension? Vasc Med. 2023 Jun 1:1358863X231175183. doi: 10.1177/1358863X231175183. Epub ahead of print. PMID: 37259519
Hurley K, Ryan M, Puffenberger D, Parker-Davis T, Bensitel A, Liu X, Cameron SJ, Tefera L. Psychological distress in pulmonary embolism survivors in a pulmonary embolism response team clinic: Protocol for a prospective observational study. Res Pract Thromb Haemost. 2023 Jan 13;7(2):100045. doi: 10.1016/j.rpth.2023.100045. PMID: 36876285
Nasser MF, Jabri A, Sharma S, Alhuneafat L, Omar YA, Krishnan V, Cameron SJ. Outcomes with use of extra-corporeal membrane oxygenation in high-risk pulmonary embolism: a national database perspective. J Thromb Thrombolysis. 2023 Apr;55(3):499-505. doi: 10.1007/s11239-023-02773-2. Epub 2023 Jan 20. PMID: 36662443.
Sedhom R, Elbadawi A, Megaly M, Athar A, Bharadwaj AS, Prasad V, Cameron SJ, Weinberg I, Mamas MA, Messerli AW, Jaber W, Elgendy IY. Outcomes with catheter-directed thrombolysis vs. catheter-directed embolectomy among patients with high-risk pulmonary embolism: a nationwide analysis. Eur Heart J Acute Cardiovasc Care. 2023 Apr 17;12(4):224-231. doi: 10.1093/ehjacc/zuad004. PMID: 36738291.Select Publications in 2022
Groth CM, Acquisto NM, Wright C, Marinescu M, McNitt S, Goldenberg I, Cameron SJ. Pharmacists as members of an interdisciplinary pulmonary embolism response team. J Am Coll Clin Pharm. 2022 Apr;5(4):390-397. doi: 10.1002/jac5.1569. Epub 2021 Nov 22. PMID: 35813573; PMCID: PMC9269076. Iskandar JP, Hariri E, Kanaan C, Kassis N, Kamran H, Sese D, Wright C, Marinescu M, Cameron SJ. The safety and efficacy of systemic versus catheter-based therapies: application of a prognostic model by a pulmonary embolism response team. J Thromb Thrombolysis. 2022 Apr;53(3):616-625. doi: 10.1007/s11239-021-02576-3. Epub 2021 Sep 29. PMID: 34586572.Elbadawi A, Mahmoud AA, Mahmoud K, Elgendy IY, Omer MA, Elsherbeny A, Ogunbayo GO, Cameron SJ, Ghanta R, Paniagua D, Jimenez E, Jneid H. Temporal Trends and Outcomes of Elective Thoracic Aortic Repair and Acute Aortic Syndromes in Bicuspid Aortic Valves: Insights from a National Database. Cardiol Ther. In press 2022.
Auron M, Aguilar MP, Cameron SJ. COVID-19 and Elevated D-Dimer: A Tale of Caution. J Gen Intern Med. 2022 Jan 6:1–2.
Select Publications in 2021
Godwin MD, Aggarwal A, Hilt Z, Shah S, Gorski J, Cameron SJ. Sex-Dependent Effect of Platelet Nitric Oxide: Production and Platelet Reactivity in Healthy Individuals. JACC Basic Transl Sci. 2021 Dec 8;7(1):14-25. https://www.sciencedirect.com/science/article/pii/S2452302X21003168?via%3Dihub
Wright C, Goldenberg I, Schleede S, McNitt S, Gosev I, Pietropaoli A, Barrus B, Elbadawi A, Chen Y, Mazzillo J, Acquisto N, Van Galen J, Hamer A, Marinescu M, Delehanty J and Cameron SJ. Effect of a Multidisciplinary Pulmonary Embolism Response Team on Patient Mortality. American Journal of Cardiology. American Journal of Cardiology 2021 Dec 15;161:102-107.
Elbadawi A, Elgend IY, Joseph D, Eze-Nliam C, Rampersad P, Ouma G , Bhandari R, Kirksey L, Chaudhury P, Chung MK, Kalra A, Mehta N, Bartholomew JR, Sahai A, Svensson LG, Cameron SJ. Racial differences, clinical presentation, and outcomes among hospitalized patients with COVID-19. Journal of Racial and Ethnic Health Disparities. In press 2021.
Kamran H, Hariri E, Iskandar JP, Sahai A, Haddadin I, Campbell J, Harb SC, Delehanty JM, Bartholomew JR, Heresi G, Cameron SJ. Simultaneous Pulmonary Artery Pressure and Left Ventricle Stroke Volume Assessment Predicts Adverse Events in Patients with Pulmonary Embolism. J American Heart Association. In press 2021.
Sahai A, Bhandari B, Koupenova M, Freedman J, Godwin M, McIntyre M, Chung M, Iskander JP, Kamran H, Hariri E, Aggarwal A, Kalra A, Bartholomew JR, McCrae KR, Elbadawi A, Svensson LG, Kapadia S, Cameron SJ. The Effect of Aspirin on Short-term Outcomes in Hospitalized Patients with SARS-CoV-2. Vascular Medicine. In press 2021. *Equally-contributing
Tefera L and Cameron SJ Vaccine-Induced Thrombocytopenia with Thrombosis. Vascular Medicine. In press 2021.
Koupenova M, Corkrey HA, Vitseva O, Tanriverdi K, Somasundaran M, Liu P, Soofi S, Bhandari R, Godwin M, Parsi KM, Cousineau A, Maehr R, Wang J, Cameron SJ, Rade JJ, Finberg RW, Freedman JE. SARS-CoV-2 Initiates Programmed Cell Death in Platelets. Circ Res. 2021 Jul 23. doi: 10.1161/CIRCRESAHA.121.319117. Epub ahead of print. PMID: 34293929.
Bhandari R and Cameron SJ Breaking the cycle: Succinate in aortic diseases. European Heart Journal. In press 2021.
Cameron, SJ and Engel, R Keeping an Eye on Vascular Disease. Vascular Medicine. In press 2021.
Chung MK, Zidar D, Bristow M, Cameron SJ, Chan T, Harding III CV, Kwon DH Singh T, Tilton J, Tsai EJ, Tucker NR, Barnard J, Loscalzo J. Update on COVID-19 and Cardiovascular Disease: from Bench to Bedside. Circ Res. 2021 Apr 16;128(8):1214-1236
Xu S, Ilyas I,. Little PJ, Li H, Kamato D, Watts S, Ebong E, Cameron SJ, Stewart AG, Weng J. Endothelial dysfunction in atherosclerotic cardiovascular diseases and beyond: from mechanism to pharmacotherapies. Pharmacol Rev. 2021 Jul;73(3):924-967
Kim BS, Auerbach DA, *Sadhra H, Godwin M, Bhandari R, Ling FS, Mohan A, Yule DI, Wagner II L, Rich DQ, Ture SK, Morrell CN, Timpanaro-Perrotta, Younis A, Goldenberg I, Cameron SJ. Sex-specific platelet activation through Protease-Activated Receptors Reverses in Myocardial Infarction. ATVB 2021 Jan;41(1):390-400. https://www.ahajournals.org/doi/pdf/10.1161/ATVBAHA.120.315033
Elbadawi A, Eldendy IY, Sahai A, Bhandari R, McCarthy M, Gomes M, Bishop GJ, Bartholomew JR, Kapadia S, Cameron SJ. Incidence and Outcomes of Thrombotic Events in Symptomatic Patients with COVID-19. ATVB 2021 Jan;41(1):545-547.https://www.ahajournals.org/doi/pdf/10.1161/ATVBAHA.120.315304
Van Galen J, Pava L, Wright C, Elbadawi A, Chaturvedi A, Cameron SJ. Effect of platelet inhibitors on thrombus burden in patients with acute pulmonary embolism. Platelets. 2021 Jan 2;32(1):138-140. https://www.tandfonline.com/doi/abs/10.1080/09537104.2020.1732329?journalCode=iplt20
Publications in 2020
Tran M, Sheth C , Bhandari R Cameron SJ, Hornacek D. SARS-CoV-2 and Pulmonary Embolism: who stole the platelets? Thromb J. 2020 Sep 3;18:16. doi: 10.1186/s12959-020-00229-8. eCollection Thromb J. 2020 Sep 3;18:16 https://thrombosisjournal.biomedcentral.com/articles/10.1186/s12959-020-00229-8
Barnes GD, Muzikansky A, Cameron S et al. Comparison of 4 Acute Pulmonary Embolism Mortality Risk Scores in Patients Evaluated by Pulmonary Embolism Response Teams. JAMA Network Open 2020 Aug 3;3(8):e2010779.
Lachant D, Bach C, Wilson B, Chengazi V, Goldman B, Lachant N, Pietropaoli A, Cameron S, James White R. Clinical and imaging outcomes after intermediate- or high-risk pulmonary embolus. Pulm Circ. 2020 Sep 21
Chung MK, Karnik S, Saef J, Bergmann C, Barnard J, Lederman MM, Tilton J, Cheng F, Harding CV, Young JB, Mehta N, Cameron SJ, McCrae KR, Schmaier, AH, Smith JD, Kalra A, Surafel GK, Thomas G, Hawkins ES, Svensson LG. SARS-CoV-2 and ACE2: The Biology and Clinical Data Behind the ARB and ACEI Controversy. EBioMedicine 2020 Aug;58:102907
Bennett J, Mastrangelo M, Ture S, Smith C, Loelius S, Berg R, Shi X, Burke R, Spinelli S, Cameron SJ, Carey T, Brookes P, Gerszten R, Sabater-Lleal M, De Vries P, Huffman J, Smith N, Morrell C, and Lowenstein CJ. The choline transporter Slc44a2 controls platelet activation and thrombosis by regulating mitochondrial function. Nature Communications 2020 Jul 13;11(1):3479.
Elbadawi A, Omer M, Ogunbayo G, Owens III, AP, Mix D, Lyden SP and Cameron SJ. Anti-platelet Medications Protect against Aortic Dissection and Rupture in Patients with Abdominal Aortic Aneurysms. Journal of the American College of Cardiology. 2020 Apr 7;75(13):1609-1610. doi: 10.1016/j.jacc
Ayers B, Wood K, Cameron SJ, Marinescu M, Bjelic M, Barrus B and Gosev I. Surgical Pulmonary Embolectomy with No Systemic Anticoagulation for Patient with Recent Stroke. In Press, Annals of Thoracic Surgery (2020)
Kamran H, Hornacek D, Mix M, Wright C, Cameron SJ. The Teachable Art of the Vascular Physical Exam. Vasc Med. 2020 Aug;25(4):351-353. https://journals.sagepub.com/doi/10.1177/1358863X20924100?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed
Stewart L, Beam B, Casciani T, Cameron SJ and Kline JE. Effect of metabolic syndrome on mean pulmonary arterial pressures in patients with acute pulmonary embolism treated with catheter-directed thrombolysis. International Journal of Cardiology. Int J Cardiol. 2020 Mar 1;302:138-142. doi: 10.1016/j.ijcard.2019
Wu MQ, Preslar M, Katerji H, Palma C, and Cameron SJ, Fibrosis, Thrombosis, and Dacrocytosis: An Unusual Case of Male Systemic Lupus Erythematosus". American J Medicine, In Press 2020. https://www.amjmed.com/article/S0002-9343(19)31103-9/fulltext
Select Publications Prior to 2019
Chen YL, Wright C, Pietropaoli AP, Elbadawi A, Delehanty J, Barrus B, Gosev I, Trawick D, Patel D, Cameron SJ. Right ventricular dysfunction is superior and sufficient for risk stratification by a pulmonary embolism response team. J Thromb Thrombolysis. 2019 Aug 2;. doi: 10.1007/s11239-019-01922-w. PubMed PMID: 31375993.
Wang M, Hopke PK, Masiol M, Thurston SW, Cameron SJ, Ling F, van Wijngaarden E, Croft D, Squizzato S,Thevenet-Morrison K, Chalupa D, Rich, DQ Triggering of ST-elevation myocardial infarction by particulate air pollution in Monroe County, New York; before, during, and after multiple air quality policies and economic changes. Environ Health. 2019 Sep 6;18(1):82. https://ehjournal.biomedcentral.com/articles/10.1186/s12940-019-0521-3
Wright C, Elbadawi A, Chen YL, Patel D, Mazzillo J, Acquisto N, Groth C, Van Galen J, Delehanty J, Pietropaoli A, Trawick D, James White R, Cameron P, Gosev I, Barrus B, Kumar NG, Cameron SJ. The impact of a pulmonary embolism response team on the efficiency of patient care in the emergency department. J Thromb Thrombolysis. 2019 Aug;48(2):331-335. doi: 10.1007/s11239-019-01875-0. PubMed PMID: 31102160.
Elbadawi A, Mentias A, Elgendy IY, Mohamed AH, Syed MH, Ogunbayo GO, Olorunfemi O, Gosev I, Prasad S, Cameron SJ. National trends and outcomes for extra-corporeal membrane oxygenation use in high-risk pulmonary embolism. Vasc Med. 2019 Jun;24(3):230-233. doi: 10.1177/1358863X18824650. Epub 2019 Mar 5. PubMed PMID: 30834824.
Elbadawi A, Wright C, Patel D, Chen YL, Mazzillo J, Cameron P, Barnes GD, Cameron SJ. The impact of a multi-specialty team for high risk pulmonary embolism on resident and fellow education. Vasc Med. 2018 Aug;23(4):372-376. doi: 10.1177/1358863X18767753. Epub 2018 May 22. PubMed PMID: 29786477.
Hilt ZT, Pariser DN, Ture SK, Mohan A, Quijada P, Asante A, Cameron SJ, Sterling JA, Merkel AR, Johanson AL, Jenkins JL, Small EM, McGrath KE, Palis J, Elliott MR, Morrell CN. Platelet-derived β2M regulates monocyte inflammatory responses. https://insight.jci.org/articles/view/122943 JCI Insight. 2019 Mar 7;4(5). PMID: 30702442
Schmidt RA, Morrell CN, Ling FS, Simlote P, Fernandez G, Rich DQ, Adler D, Gervase J, Cameron SJ. The platelet phenotype in patients with ST-segment elevation myocardial infarction is different from non-ST-segment elevation myocardial infarction. Transl Res. 2018 May;195:1-12. doi: 10.1016/j.trsl.2017.11.006. Epub 2017 Dec 2. PubMed PMID: 29274308.
Gleber C, Yoruk A, Eastburg L, Goldman BI, Cameron SJ. Conduction Dysfunction and Near Expunction: Giant Cell Myocarditis. Am J Med. 2018 Nov;131(11):1317-1320. doi: 10.1016/j.amjmed.2018.04.011. Epub 2018 May 3. PubMed PMID: 29729236.
Cameron SJ, Mix D, Ture S, Schmidt R, Mohan A, Pariser D, Stoner M, Shah P, Chen L, Zhang H, Field DJ, Modjeski KL, Toth S, Morrell CN. "Hypoxia and Ischemia Promote a Maladaptive PlateletPhenotype". https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6023774/ Atherosclerosis Thrombosis and Vascular Biology. 2018; 38(7): 1594-1606.
Croft D, Block R, Cameron SJ, Evans K, Lowenstein CJ, Ling F, Zareba W, Hopke PK, Utell MJ, Thurston SW, Thevenet-Morrison K, Rich DQ. Do elevated blood levels of omega-3 fatty acids modify effects of particulate air pollutants on fibrinogen?. Air Qual Atmos Health. 2018;11(7):791-799. doi: 10.1007/s11869-018-0586-0. Epub 2018 Jun 3. PubMed PMID: 30147809.
Yang M, Cooley BC, Li W, Chen Y, Vasquez-Vivar J, Scoggins NO, Cameron SJ, Morrell CN, Silverstein RL. Platelet CD36 promotes thrombosis by activating redox sensor ERK5 in hyperlipidemic conditions. Blood. 2017 May 25;129(21):2917-2927. doi: 10.1182/blood-2016-11-750133. Epub 2017 Mar 23. PubMed PMID: 28336528
Miller EO, Krishnamoorthy VK, Ling FSK, Chaturvedi A, Cameron SJ. A man with chest pain and acute ST elevations on electrocardiogram. BMJ. 2017 May 18;357:j2198. doi: 10.1136/bmj.j2198. PubMed PMID: 28522610.
Croft DP, Cameron SJ, Morrell CN, Lowenstein CJ, Ling F, Zareba W, Hopke PK, Utell MJ, Thurston SW, Thevenet-Morrison K, Evans KA, Chalupa D, Rich DQ. Associations between ambient wood smoke and other particulate pollutants and biomarkers of systemic inflammation, coagulation and thrombosis in cardiac patients. Environ Res. 2017 Apr;154:352-361. doi: 10.1016/j.envres.2017.01.027. Epub 2017 Feb 4. PubMed PMID: 28167447.
Cameron SJ, Morrell CN, Bao C, Swaim AF, Rodriguez A, Lowenstein CJ. A Novel Anti-Inflammatory Effect for High Density Lipoprotein. PLoS One. 2015;10(12):e0144372. doi: 10.1371/journal.pone.0144372. eCollection 2015. PubMed PMID: 26680360
Cameron SJ, Ture SK, Mickelsen D, Chakrabarti E, Modjeski KL, McNitt S, Seaberry M, Field DJ, Le NT, Abe JI, Morrell CN. "Platelet Extracellular Regulated Protein Kinase 5 Is a Redox Switch and Triggers Maladaptive Platelet Responses and Myocardial Infarct Expansion." Circulation.. 2015 Jul 7; 132(1):47-58. Epub 2015 May 01.
Gardner B, Ling, FL Hopke PK, Frampton MW, Utell MJ, Zareba W, Cameron SJ, Chalupa D, Kane C, Kulandhaisamy S, Topf M, Rich, DQ. Ambient fine particulate air pollution triggers ST elevationmyocardial infarction, but not non-ST-elevation myocardial infarction: a case-crossover study. Part Fibre Toxicol. 2014 Jan 2;11(1):1. PMID: 24382024
Jeong Y, Chaupin DF, Matsushita K, Yamakuchi M, Cameron SJ, Morrell CN, Lowenstein CJ. Aldosterone activates endothelial exocytosis. Proc Natl Acad Sci U S A. 2009 Mar 10;106(10):3782-7. doi: 10.1073/pnas.0804037106. Epub 2009 Feb 17. PubMed PMID: 19223584.
Frame MD, Rivers RJ, Altland O, Cameron SJ Mechanisms initiating integrin-stimulated flow recruitment in arteriolar networks. J Applied Physiology 2007 Jun;102(6):2279-87. PMID: 17379749.
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Research News
Platelet protein GPVI was revealed as a biomarker for abdominal aortic aneurysm screening (AAA).
The program, which has funded 21 research teams since 2015, has a proven record of supporting projects that go on to attract large external grants.
Dr. Cameron will study the mechanistic interaction between platelets and how they emerge as circulating biosensors, releasing proteins that are useful biomarkers for distinguishing fast- from slow-growing aneurysms.