George Muschler, MD
Staff
Director, Orthopaedic and Rheumatologic Research Center
Director, Clinical Tissue Engineering Center (CTEC)
Director, Joint Preservation Center
Location: Cleveland Clinic Main Campus
Research
Our future health requires that we constantly repair and replace the tissues that we lose each day to natural processes, injury, degeneration or disease. Our laboratory is focused on developing and testing new cell-based therapies for patients who suffer conditions that result in the loss of healthy tissue, including fractures, bone loss (osteoporosis), arthritis and cartilage injuries. We are also developing new methods and standards for measuring the number of stem and progenitor cells in different tissues of the body, to advance the entire field of cell and gene therapy These methods can provide a new way to assess the health or disease state of a specific tissue and allow for the development of new cell therapies.
Biography
George Muschler, MD, joined the Department of Orthopaedic Surgery in 1988. Since his arrival, he has developed a regional and national reputation in reconstructive surgery for arthritis, failed joint replacements, treatment of fractures that have failed to heal and treatment of limb deformities. He is recognized and appreciated internationally as a leader in skeletal reconstruction, bone regeneration and fracture repair. In 1999, he was appointed Research Associate in the Cleveland Clinic Office of Clinical Effectiveness, due to his work in establishing a program of patient-oriented outcomes assessment for hip and knee replacements performed in the Department of Orthopaedic Surgery. Dr. Muschler is also a member of Cleveland Clinic Taussig Cancer Center, leading and collaborating in research related to aging and adult stem cell therapies and transplantation.
In addition to his commitment to patient care, Dr. Muschler is a Vice-Chairman of the Department of Biomedical Engineering within the Cleveland Clinic's Lerner Research Institute. There he directs the Bone Biology Laboratory. This laboratory is supported by the National Institutes of Health and other funding agencies, and is focused on development of improved methods for tissue engineering and regenerative medicine. This work has provided insight into the effects of aging on stem cells of bone and cartilage, and the importance and application of these cells in development of osteoporosis, bone diseases and in the broader area of tissue repair, including bone, cartilage, tendon, nerve, muscle and skin.
Dr. Muschler has become a leader in the development of collaborative interdisciplinary programs and research teams in the area of tissue engineering and regenerative medicine, contributing significantly to both regional and national development of translational research leading to new products and therapeutic strategies. In 2005, he and colleagues at Cleveland Clinic, Case Western Reserve University, University Hospitals, NASA Glenn Research Center and the Ohio Super Computer Center established the Clinical Tissue Engineering Center (CTEC), through a grant from the Ohio Third Frontier Program. CTEC continues to serve as a catalyst for research and collaboration in the development and assessment of new therapies between over 70 Ohio investigators and over 10 Ohio institutions.
Dr. Muschler and CTEC participate in the National Center for Regenerative Medicine (NCRM), a collaboration between Cleveland Clinic and Case Western Reserve University, where he serves in the Executive Committee.
Since 2007, Dr. Muschler has served as Vice Chairman of the Orthopaedic and Rheumatologic Institute at the Cleveland Clinic, focusing efforts in the area of Research and Clinical Quality Assessment and Management.
In 2007, Dr. Muschler became Co-Director of the Armed Forces Institute for Regenerative Medicine (AFIRM), which is now an integrated national network of leading scientists and clinicians at 28 other institutions dedicated to developing new methods for treating battlefield injuries sustained by US service members.
Education & Professional Highlights
Education & Fellowships
Fellowship - Weill Cornell Medical, Hospital for Special Surgery
Orthopaedic Surgery
New York, NY USA
1988
Fellowship - Memorial Sloan-Kettering Cancer Center
Musculoskeletal Oncology
New York, NY USA
1988
Residency - University of Texas Southwestern Medical Center at Dallas
Orthopedic Surgery
Dallas, TX USA
1986
Internship - University of Texas Southwestern Medical Center at Dallas
Surgical Internship
Dallas, TX USA
1982
Medical Education - Northwestern University Feinberg School of Medicine
Chicago, IL USA
1981
Undergraduate - University of Illinois Hospital at Urbana-Champaign
Chemistry
Urbana, IL USA
1977
Professional Highlights
- Director, Orthopaedic and Rheumatologic Research Center, 2005-Present
- Director, Clinical Tissue Engineering Center (CTEC), 2005-Present
- Vice Chairman, Department of Biomedical Engineering, 2004-Present
- Vice Chairman for Research, Cleveland Clinic Orthopaedic and Rheumatologic Institute, 2007-Present
- Co-Director, Armed Forces Institute for Regenerative Medicine (AFIRM), 2007-Present
Awards & Honors
- North American Traveling Fellowship, American Orthopaedic Association, 1989
- Career Development Award, Orthopaedic Research and Education Foundation, 1990-1992
- J.P Ranney Award for Innovation in Regenerative Medicine and Stem Cell Research, 2006
- Clevelands Best Doctors, Northern Ohio Live magazine, 2007
Innovations & Patents
- Innovator in both implant design for joint surgery and limb reconstruction, as well as in the application of biological principles to the regeneration of new tissues, particularly bone.
- Responsible for over nine patents and recognized as inventor of the concept of selective retention as a means of rapidly concentrating and delivering a patient's own stem cells for use in tissue-healing applications. This is the basis for the Cellect TM Device, that has now been used in treatment of over 50,000 patients worldwide for bone repair following spine surgery or fractures.
Memberships
- American Academy of Orthopaedic Surgeons
- Orthopaedic Research Society
- American Orthopaedic Association
- Association of Bone and Joint Surgeons
- International Society for Tissue Engineering
- International Society for Stem Cell Research
- American Society for Bone and Mineral Research
Research
Our laboratory is focused on advancing the field of tissue engineering and regenerative medicine through development of new strategies for preservation, repair, regeneration, augmentation, or replacement of musculoskeletal tissues. We focus on four key areas: 1) the harvest, processing and transplantation of adult connective tissue stem cells and progenitors (CTPs) for treatment of fractures and problems of degenerative joints; 2) the effects of aging and osteoporosis on CTPs; 3) optimizing assays for CTPs and other stem cells; 4) the development of advanced automation instruments and methods for rigorous reproducible cell processing. Methods that we have developed to measure the number and function of CTPs, and to harvest, concentrate, select and transplant CTPs, are already widely used by scientists and surgeons.
Our Team
Selected Publications
View publications for George Muschler, MD
(Disclaimer: This search is powered by PubMed, a service of the U.S. National Library of Medicine. PubMed is a third-party website with no affiliation with Cleveland Clinic.)
Cleveland Clinic OME Arthroplasty Group, Siddiqi A, Warren J, Anis HK, Barsoum WK, Bloomfield MR, Briskin I, Brooks PJ, Higuera CA, Kamath AF, Klika A, Krebs O, Krebs VE, Mesko NW, Molloy RM, Mont MA, Murray TG, Muschler GF, Patel P, Stearns KL, Strnad GJ, Suarez JC, Piuzzi NS. Do patient-reported outcome measures improve after aseptic revision total hip arthroplasty? Hip Int. 2021 Sep 23:11207000211036320. doi: 10.1177/11207000211036320. Epub ahead of print. PMID: 34554849.
Frank RM, Sherman SL, Chahla J, Dragoo JL, Mandelbaum B; Members of the Biologic Association, Anz AW, Bradley JP, Chu CR, Cole BJ, Farr J, Flanigan DC, Gomoll AH, Halbrecht J, Horsch K, Lattermann C, Leucht P, Maloney WJ, McIntyre LF, Murray I, Muschler GF, Nakamura N, Piuzzi NS, Rodeo SA, Saris DBF, Shaffer WO, Shapiro SA, Spindler KP, Steinwachs M, Tokish JM, Vangsness CT, Watson JT, Yanke AB, Zaslav KR. Biologic Association Annual Summit: 2020 Report. Orthop J Sports Med. 2021 Jun 7;9(6):23259671211015667. doi: 10.1177/23259671211015667. PMID: 34164559; PMCID: PMC8191082.
Mantripragada VP, Piuzzi NS, Muschler GF, Erdemir A, Midura RJ. A comprehensive dataset of histopathology images, grades and patient demographics for human Osteoarthritis Cartilage. Data Brief. 2021 May 14;37:107129. doi: 10.1016/j.dib.2021.107129. PMID: 34113698; PMCID: PMC8170068.
Patient Age and Cell Concentration Influence Prevalence and Concentration of Progenitors in Bone Marrow Aspirates: An Analysis of 436 Patients. J Bone Joint Surg Am. 2021 Apr 12. doi: 10.2106/JBJS.20.02055. Online ahead of print.
Cleveland Clinic OME Arthroplasty Group:, Bircher JB, Kamath AF, Piuzzi NS, Barsoum WK, Brooks PJ, Hampton RJ, Higuera CA, Klika A, Krebs VE, Mesko NW, Molloy RM, Mont MA, Murray TG, Muschler GF, Nickodem RJ, Patel PD, Spindler KP, Stearns KL, Strnad GJ, Suarez JC, Warren JA, Zajicheck A, Bloomfield MR. No clinically meaningful difference in 1-year patient-reported outcomes among major approaches for primary total hip arthroplasty. Hip Int. 2021 Mar 7:1120700021992013. doi: 10.1177/1120700021992013. Online ahead of print.
Cleveland Clinic OME Arthroplasty Group. Understanding the Main Predictors of Length of Stay After Total Hip Arthroplasty: Patient-Related or Procedure-Related Risk Factors? J Arthroplasty. 2021 May;36(5):1663-1670.e4. doi: 10.1016/j.arth.2020.11.029.
Mantripragada VP, Tan KL, Vasavada S, Bova W, Barnard J, Muschler GF. Characterization of heterogeneous primary human cartilage-derived cell population using non-invasive live-cell phase-contrast time-lapse imaging. Cytotherapy. 2020 Oct 19:S1465-3249(20)30862-8. doi: 10.1016/j.jcyt.2020.09.006.
Siddiqi A, Higuera-Rueda CA, Krebs VE, Molloy RM, Klika A, Piuzzi NS; the Cleveland Clinic OME Arthroplasty Group. Patient-Reported Outcome Measures (Pain, Function, and Quality of Life) After Aseptic Revision Total Knee Arthroplasty. J Bone Joint Surg Am. 2020 Oct 21;102(20):e114. doi: 10.2106/JBJS.19.01155.
Roth A, Anis HK, Emara AK, Klika AK, Barsoum WK, Bloomfield MR, Brooks PJ, Higuera CA, Kamath AF, Krebs VE, Mesko NW, Murray TG, Muschler GF, Nickodem RJ, Patel PD, Schaffer JL, Stearns KL, Strnad G, Warren JA, Zajichek A, Mont MA, Molloy RM, Piuzzi NS; Cleveland Clinic OME Arthroplasty Group. The Potential Effects of Imposing a Body Mass Index Threshold on Patient-Reported Outcomes After Total Knee Arthroplasty. J Arthroplasty. 2020 Sep 8:S0883-5403(20)30969-4. doi: 10.1016/j.arth.2020.08.060.
Mantripragada VP, Luangphakdy V, Hittle B, Powell K, Muschler GF. Automated in-process characterization and selection of cell-clones for quality and efficient cell manufacturing. Cytotechnology. 2020 Oct;72(5):615-627. doi: 10.1007/s10616-020-00403-w.
Rajan PV, Ng MK, Klika A, Kamath AF, Muschler GF, Higuera CA, Piuzzi NS. The Cost-Effectiveness of Platelet-Rich Plasma Injections for Knee Osteoarthritis: A Markov Decision Analysis. J Bone Joint Surg Am. 2020 Sep 16;102(18):e104. doi: 10.2106/JBJS.19.01446.
Mantripragada VP, Kaplevatsky R, Bova WA, Boehm C, Obuchowski NA, Midura RJ, Muschler GF. Influence of Glucose Concentration on Colony-Forming Efficiency and Biological Performance of Primary Human Tissue-Derived Progenitor Cells. Cartilage. 2020 Feb 26:1947603520906605. doi: 10.1177/1947603520906605.
Murray IR, Chahla J, Frank RM, Piuzzi NS, Mandelbaum BR, Dragoo JL; Members of the Biologics Association. Rogue stem cell clinics. Bone Joint J. 2020 Feb;102-B(2):148-154. doi: 10.1302/0301-620X.102B2.BJJ-2019-1104.R1. PMID: 32009438 Free PMC article.
OME Cleveland Clinic Orthopaedics. Value in Research: Achieving Validated Outcome Measurements While Mitigating Follow-up Cost. J Bone Joint Surg Am. 2020 Mar 4;102(5):419-427. doi: 10.2106/JBJS.19.00531.
Mantripragada VP, Bova WA, Piuzzi NS, Boehm C, Obuchowski NA, Midura RJ, Muschler GF. Native-Osteoarthritic Joint Resident Stem and Progenitor Cells for Cartilage Cell-Based Therapies: A Quantitative Comparison With Respect to Concentration and Biological Performance. Am J Sports Med. 2019 Dec;47(14):3521-3530. doi: 10.1177/0363546519880905.
Piuzzi NS, Anis HK, Muschler GF. Osteonecrosis of the femoral head with subchondral collapse. Cleve Clin J Med. 2019 Aug;86(8):511-512. doi: 10.3949/ccjm.86a.19004.
Mantripragada VP, Piuzzi NS, George J, Bova W, Ng M, Boehm C, Muschler GF. Reliable assessment of bone marrow and bone marrow concentrates using automated hematology analyzer. Regen Med. 2019 Jul;14(7):639-646. doi: 10.2217/rme-2018-0173.
Chughtai M, Kamath AF; Cleveland Clinic Arthroplasty Group. No Evidence to Support Lowering Surgeon Reimbursement for Total Joint Arthroplasty Based on Operative Time: An Institutional Review of 12,567 Cases. J Arthroplasty. 2019 Nov;34(11):2523-2527. doi: 10.1016/j.arth.2019.06.028.
Lowry KJ, Brox WT, Naas PL, Tubb CC, Muschler GF, Dunn W. Musculoskeletal-based Patient-reported Outcome Performance Measures, Where Have We Been-Where Are We Going. J Am Acad Orthop Surg. 2019 Jul 1;27(13):e589-e595. doi: 10.5435/JAAOS-D-18-00429.
Piuzzi NS, Strnad GJ, Sakr Esa WA, Barsoum WK, Bloomfield MR, Brooks PJ, Higuera-Rueda CA, Joyce MJ, Kattan MW, Klika AA, Krebs V, Mesko NW, Mont MA, Murray TG, Muschler GF, Nickodem RJ, Patel PD, Schaffer JL, Spindler KP, Stearns KL, Suarez JC, Zajichek A, Molloy RM; Cleveland Clinic Orthopaedic Arthroplasty Group. The Main Predictors of Length of Stay After Total Knee Arthroplasty: Patient-Related or Procedure-Related Risk Factors. J Bone Joint Surg Am. 2019 Jun 19;101(12):1093-1101. doi: 10.2106/JBJS.18.00758.
Scully W, Piuzzi NS, Sodhi N, Sultan AA, George J, Khlopas A, Muschler GF, Higuera CA, Mont MA. The effect of body mass index on 30-day complications after total hip arthroplasty. Hip Int. 2020 Mar;30(2):125-134. doi: 10.1177/1120700019826482
Piuzzi NS, Ng M, Chughtai M, Khlopas A, Ramkumar PN, Harwin SF, Mont MA, Bauer TW, Muschler GF. Accelerated Growth of Cellular Therapy Trials in Musculoskeletal Disorders: An Analysis of the NIH Clinical Trials Data Bank. Orthopedics. 2019 Mar 1;42(2):e144-e150. doi: 10.3928/01477447-20190118-04.
Kwee E, Saidel G, Powell K, Heylman C, Boehm C, Muschler G. Quantifying proliferative and surface marker heterogeneity in colony-founding connective tissue progenitors and their progeny using time-lapse microscopy. J Tissue Eng Regen Med. 2019 Feb;13(2):203-216. doi: 10.1002/term.2782.
Piuzzi NS, Mantripragada VP, Kwee E, Sumski A, Selvam S, Boehm C, Muschler GF. Bone Marrow-Derived Cellular Therapies in Orthopaedics: Part II: Recommendations for Reporting the Quality of Bone Marrow-Derived Cell Populations. JBJS Rev. 2018 Nov;6(11):e5. doi: 10.2106/JBJS.RVW.18.00008.
Piuzzi NS, Mantripragada VP, Sumski A, Selvam S, Boehm C, Muschler GF. Bone Marrow-Derived Cellular Therapies in Orthopaedics: Part I: Recommendations for Bone Marrow Aspiration Technique and Safety. JBJS Rev. 2018 Nov;6(11):e4. doi: 10.2106/JBJS.RVW.18.00007.
Piuzzi NS, George J, Khlopas A, Klika AK, Mont MA, Muschler GF, Higuera CA. High prevalence and seasonal variation of hypovitaminosis D in patients scheduled for lower extremity total joint arthroplasty. Ann Transl Med. 2018 Aug;6(16):321. doi: 10.21037/atm.2018.08.21.
Piuzzi NS, Dominici M, Long M, Pascual-Garrido C, Rodeo S, Huard J, Guicheux J, McFarland R, Goodrich LR, Maddens S, Robey PG, Bauer TW, Barrett J, Barry F, Karli D, Chu CR, Weiss DJ, Martin I, Jorgensen C, Muschler GF. Proceedings of the signature series symposium "Cellular therapies for orthopaedics and musculoskeletal disease proven and unproven therapies-promise, facts and fantasy," International Society For Cellular Therapies, Montreal, Canada, May 2, 2018. Cytotherapy. 2018 Nov;20(11):1381-1400. doi: 10.1016/j.jcyt.2018.09.001.
Chu CR, Rodeo S, Bhutani N, Goodrich LR, Huard J, Irrgang J, LaPrade RF, Lattermann C, Lu Y, Mandelbaum B, Mao J, McIntyre L, Mishra A, Muschler GF, Piuzzi NS, Potter H, Spindler K, Tokish JM, Tuan R, Zaslav K, Maloney W. Optimizing Clinical Use of Biologics in Orthopaedic Surgery: Consensus Recommendations From the 2018 AAOS/NIH U-13 Conference. J Am Acad Orthop Surg. 2019 Jan 15;27(2):e50-e63. doi: 10.5435/JAAOS-D-18-00305.
Ma J, Piuzzi NS, Muschler GF, Iannotti JP, Ricchetti ET, Derwin KA. Biomarkers of Rotator Cuff Disease Severity and Repair Healing. JBJS Rev. 2018 Sep;6(9):e9. doi: 10.2106/JBJS.RVW.17.00178.
Piuzzi NS, Ng M, Kantor A, Ng K, Kha S, Mont MA, Muschler GF. What Is the Price and Claimed Efficacy of Platelet-Rich Plasma Injections for the Treatment of Knee Osteoarthritis in the United States? J Knee Surg. 2019 Sep;32(9):879-885. doi: 10.1055/s-0038-1669953.
Curtis GL, Tariq MB, Brigati DP, Faour M, Higuera CA; Cleveland Clinic Orthopaedic Arthroplasty Group. Validation of a Novel Surgical Data Capturing System Following Total Hip Arthroplasty. J Arthroplasty. 2018 Nov;33(11):3479-3483. doi: 10.1016/j.arth.2018.07.011.
Piuzzi NS, Hussain ZB, Chahla J, Cinque ME, Moatshe G, Mantripragada VP, Muschler GF, LaPrade RF. Variability in the Preparation, Reporting, and Use of Bone Marrow Aspirate Concentrate in Musculoskeletal Disorders: A Systematic Review of the Clinical Orthopaedic Literature. J Bone Joint Surg Am. 2018 Mar 21;100(6):517-525. doi: 10.2106/JBJS.17.00451.
Qadan MA, Piuzzi NS, Boehm C, Bova W, Moos M Jr, Midura RJ, Hascall VC, Malcuit C, Muschler GF. Variation in primary and culture-expanded cells derived from connective tissue progenitors in human bone marrow space, bone trabecular surface and adipose tissue. Cytotherapy. 2018 Mar;20(3):343-360. doi: 10.1016/j.jcyt.2017.11.013. Epub 2018 Feb 1.
Piuzzi NS, Midura RJ, Muschler GF, Hascall VC. Intra-articular hyaluronan injections for the treatment of osteoarthritis: perspective for the mechanism of action. Ther Adv Musculoskelet Dis. 2018 Feb;10(2):55-57. doi: 10.1177/1759720X17752038. 32
Cleveland Clinic Orthopaedic Arthroplasty. The Association Between Readmission and Patient Experience in a Total Hip Arthroplasty Population. J Arthroplasty. 2018 Jun;33(6):1668-1674. doi: 10.1016/j.arth.2017.12.023.
Piuzzi NS, Khlopas A, Sodhi N, Oak S, Sultan AA, Chughtai M, Mantripragada VP, Mont MA, Muschler GF. Cellular Therapies in Orthopedics: Where Are We? Surg Technol Int. 2017 Dec 22;31:359-364.
Lespasio MJ, Sultan AA, Piuzzi NS, Khlopas A, Husni ME, Muschler GF, Mont MA. Hip Osteoarthritis: A Primer. Perm J. 2018;22:17-084. doi: 10.7812/TPP/17-084.
Mantripragada VP, Bova WA, Boehm C, Piuzzi NS, Obuchowski NA, Midura RJ, Muschler GF. Progenitor cells from different zones of human cartilage and their correlation with histopathological osteoarthritis progression. J Orthop Res. 2018 Jun;36(6):1728-1738. doi: 10.1002/jor.23829.
Bhattaram P, Muschler G, Wixler V, Lefebvre V. Inflammatory Cytokines Stabilize SOXC Transcription Factors to Mediate the Transformation of Fibroblast-Like Synoviocytes in Arthritic Disease. Arthritis Rheumatol. 2018 Mar;70(3):371-382. doi: 10.1002/art.40386.
Piuzzi NS, Khlopas A, Newman JM, Ng M, Roche M, Husni ME, Spindler KP, Mont MA, Muschler G. Bone Marrow Cellular Therapies: Novel Therapy for Knee Osteoarthritis. J Knee Surg. 2018 Jan;31(1):22-26. doi: 10.1055/s-0037-1608844.
Mantripragada VP, Piuzzi NS, Zachos T, Obuchowski NA, Muschler GF, Midura RJ. High occurrence of osteoarthritic histopathological features unaccounted for by traditional scoring systems in lateral femoral condyles from total knee arthroplasty patients with varus alignment. Acta Orthop. 2018 Apr;89(2):197-203. doi: 10.1080/17453674.2017.1398559.
Mistry JB, Gwam CU, Chughtai M, Khlopas A, Ramkumar P, Piuzzi NS, Muschler G, Harwin SF, Mont MA, Delanois RE. Factors Influencing Patients' Hospital Rating After Total Joint Arthroplasty. Orthopedics. 2017 Nov 1;40(6):377-380. doi: 10.3928/01477447-20171019-03.
Chahla J, Cinque ME, Piuzzi NS, Mannava S, Geeslin AG, Murray IR, Dornan GJ, Muschler GF, LaPrade RF.
A Call for Standardization in Platelet-Rich Plasma Preparation Protocols and Composition Reporting: A Systematic Review of the Clinical Orthopaedic Literature. J Bone Joint Surg Am. 2017 Oct 18;99(20):1769-1779. doi: 10.2106/JBJS.16.01374.
Lespasio MJ, Piuzzi NS, Husni ME, Muschler GF, Guarino A, Mont MA. Knee Osteoarthritis: A Primer.
Perm J. 2017;21:16-183. doi: 10.7812/TPP/16-183.
Patterson TE, Boehm C, Nakamoto C, Rozic R, Walker E, Piuzzi NS, Muschler GF. The Efficiency of Bone Marrow Aspiration for the Harvest of Connective Tissue Progenitors from the Human Iliac Crest. J Bone Joint Surg Am. 2017 Oct 4;99(19):1673-1682. doi: 10.2106/JBJS.17.00094. PMID: 28976432 Free PMC article.
Wheatley BM, Cilwa KE, Dey D, Qureshi AT, Seavey JG, Tomasino AM, Sanders EM, Bova W, Boehm CA, Iwamoto M, Potter BK, Forsberg JA, Muschler GF, Davis TA. Palovarotene inhibits connective tissue progenitor cell proliferation in a rat model of combat-related heterotopic ossification. J Orthop Res. 2018 Apr;36(4):1135-1144. doi: 10.1002/jor.23747.
Ramkumar PN, Navarro SM, Haeberle HS, Chughtai M, Demetriades C, Piuzzi NS, Mont MA, Bauer TW, Muschler GF. Cellular therapy injections in today's orthopedic market: A social media analysis. Cytotherapy. 2017 Dec;19(12):1392-1399. doi: 10.1016/j.jcyt.2017.08.006.
Ng M, Song S, Piuzzi NS, Ng K, Gwam C, Mont MA, Muschler GF. Stem cell industry update: 2012 to 2016 reveals accelerated investment, but market capitalization and earnings lag. Cytotherapy. 2017 Oct;19(10):1131-1139. doi: 10.1016/j.jcyt.2017.07.006.
Piuzzi NS, Ng M, Chughtai M, Khlopas A, Ng K, Mont MA, Muschler GF. The Stem-Cell Market for the Treatment of Knee Osteoarthritis: A Patient Perspective. J Knee Surg. 2018 Jul;31(6):551-556. doi: 10.1055/s-0037-1604443
Patel NK, Kim E, Khlopas A, Chughtai M, Gwam C, Elmallah RK, Ramkumar P, Piuzzi NS, Delanois RE, Muschler G, Mont MA. What Influences How Patients Rate Their Hospital Stay After Total Hip Arthroplasty? Surg Technol Int. 2017 Jul 25;30:405-410.
Piuzzi NS, Chughtai M, Khlopas A, Harwin SF, Miniaci A, Mont MA, Muschler GF. Platelet-Rich Plasma for the Treatment of Knee Osteoarthritis: A Review. J Knee Surg. 2017 Sep;30(7):627-633. doi: 10.1055/s-0037-1603795.
Luangphakdy V, Elizabeth Pluhar G, Piuzzi NS, D'Alleyrand JC, Carlson CS, Bechtold JE, Forsberg J, Muschler GF. The Effect of Surgical Technique and Spacer Texture on Bone Regeneration: A Caprine Study Using the Masquelet Technique. Clin Orthop Relat Res. 2017 Oct;475(10):2575-2585. doi: 10.1007/s11999-017-5420-8.
Gwam C, Mistry JB, Piuzzi N, Chughtai M, Khlopas A, Thomas M, Elmallah RK, Muschler G, Mont MA, Harwin SF, Delanois RE. What Influences How Patients with Depression Rate Hospital Stay After Total Joint Arthroplasty? Surg Technol Int. 2017 Jul 25;30:373-378.
Piuzzi NS, Muschler GF. CORR Insights®: Which Clinical and Patient Factors Influence the National Economic Burden of Hospital Readmissions After Total Joint Arthroplasty. Clin Orthop Relat Res. 2017 Dec;475(12):2938-2940. doi: 10.1007/s11999-017-5324-7.
Piuzzi NS, Chahla J, Jiandong H, Chughtai M, LaPrade RF, Mont MA, Muschler GF, Pascual-Garrido C. Analysis of Cell Therapies Used in Clinical Trials for the Treatment of Osteonecrosis of the Femoral Head: A Systematic Review of the Literature. J Arthroplasty. 2017 Aug;32(8):2612-2618. doi: 10.1016/j.arth.2017.02.075.
Piuzzi N, Chughtai M, Khlopas A, Gwam CU, Muschler G, Spindler KP, Mont MA. Early Termination of Randomized Clinical Trials in Orthopaedics. Surg Technol Int. 2017 Feb 7;30:290-294.
Piuzzi NS, Chahla J, Schrock JB, LaPrade RF, Pascual-Garrido C, Mont MA, Muschler GF. Evidence for the Use of Cell-Based Therapy for the Treatment of Osteonecrosis of the Femoral Head: A Systematic Review of the Literature. J Arthroplasty. 2017 May;32(5):1698-1708. doi: 10.1016/j.arth.2016.12.049.
Kwee E, Herderick EE, Adams T, Dunn J, Germanowski R, Krakosh F, Boehm C, Monnich J, Powell K, Muschler G. Integrated Colony Imaging, Analysis, and Selection Device for Regenerative Medicine. SLAS Technol. 2017 Apr;22(2):217-223. doi: 10.1177/2211068216676587.
Ramkumar PN, Muschler GF, Spindler KP, Harris JD, McCulloch PC, Mont MA. Open mHealth Architecture: A Primer for Tomorrow's Orthopedic Surgeon and Introduction to Its Use in Lower Extremity Arthroplasty. J Arthroplasty. 2017 Apr;32(4):1058-1062. doi: 10.1016/j.arth.2016.11.019.
Chahla J, Piuzzi NS, Mitchell JJ, Dean CS, Pascual-Garrido C, LaPrade RF, Muschler GF. Intra-Articular Cellular Therapy for Osteoarthritis and Focal Cartilage Defects of the Knee: A Systematic Review of the Literature and Study Quality Analysis. J Bone Joint Surg Am. 2016 Sep 21;98(18):1511-21. doi: 10.2106/JBJS.15.01495.
Marcucio RS, Nauth A, Giannoudis PV, Bahney C, Piuzzi NS, Muschler G, Miclau T 3rd. Stem Cell Therapies in Orthopaedic Trauma. J Orthop Trauma. 2015 Dec;29 Suppl 12(Suppl 12):S24-7. doi: 10.1097/BOT.0000000000000459.
Luangphakdy V, Boehm C, Pan H, Herrick J, Zaveri P, Muschler GF. Assessment of Methods for Rapid Intraoperative Concentration and Selection of Marrow-Derived Connective Tissue Progenitors for Bone Regeneration Using the Canine Femoral Multidefect Model. Tissue Eng Part A. 2016 Jan;22(1-2):17-30. doi: 10.1089/ten.TEA.2014.0663.
Joshi P, Williams PS, Moore LR, Caralla T, Boehm C, Muschler G, Zborowski M. Circular Halbach array for fast magnetic separation of hyaluronan-expressing tissue progenitors. Anal Chem. 2015 Oct 6;87(19):9908-15. doi: 10.1021/acs.analchem.5b02431.
Heylman CM, Caralla TN, Boehm CA, Patterson TE, Muschler GF. Slowing the Onset of Hypoxia Increases Colony Forming Efficiency of Connective Tissue Progenitor Cells In Vitro. J Regen Med Tissue Eng. 2013 Sep 26;2:10.7243/2050-1218-2-7. doi: 10.7243/2050-1218-2-7.
Heylman CM, Santoso S, Krebs MD, Saidel GM, Alsberg E, Muschler GF. Modeling and experimental methods to predict oxygen distribution in bone defects following cell transplantation. Med Biol Eng Comput. 2014 Apr;52(4):321-30. doi: 10.1007/s11517-013-1133-7.
Kim EJ, Fleischman AJ, Muschler GF, Roy S. Response of bone marrow derived connective tissue progenitor cell morphology and proliferation on geometrically modulated microtextured substrates. Biomed Microdevices. 2013 Jun;15(3):385-96. doi: 10.1007/s10544-012-9727-7.
Heylman CM, Caralla TN, Boehm CA, Patterson TE, Muschler GF. Slowing the onset of hypoxia increases colony forming efficiency of connective tissue progenitor cells in vitro. J Reg Med and Tissue Eng 2013 Sept; 2(7).
Luangphakdy V, Walker E, Shinohara K, Pan H, Hefferan T, Bauer TW, Stockdale L, Saini S, Dadsetan M, Runge MB, Vasanji A, Griffith L, Yaszemski M, Muschler GF. Evaluation of osteoconductive scaffolds in the canine femoral multi-defect model. Tissue Eng Part A. 2013 Mar;19(5-6):634-48. doi: 10.1089/ten.TEA.2012.0289.
Caralla T, Joshi P, Fleury S, Luangphakdy V, Shinohara K, Pan H, Boehm C, Vasanji A, Hefferan TE, Walker E, Yaszemski M, Hascall V, Zborowski M, Muschler GF. In vivo transplantation of autogenous marrow-derived cells following rapid intraoperative magnetic separation based on hyaluronan to augment bone regeneration. Tissue Eng Part A. 2013 Jan;19(1-2):125-34. doi: 10.1089/ten.tea.2011.0622.
Caralla T, Boehm C, Hascall V, Muschler G. Hyaluronan as a novel marker for rapid selection of connective tissue progenitors. Ann Biomed Eng. 2012 Dec;40(12):2559-67. doi: 10.1007/s10439-012-0608-2.
Tomek IM, Sabel AL, Froimson MI, Muschler G, Jevsevar DS, Koenig KM, Lewallen DG, Naessens JM, Savitz LA, Westrich JL, Weeks WB, Weinstein JN. A collaborative of leading health systems finds wide variations in total knee replacement delivery and takes steps to improve value. Health Aff (Millwood). 2012 Jun;31(6):1329-38. doi: 10.1377/hlthaff.2011.0935.
Kumagai K, Takeuchi R, Ishikawa H, Yamaguchi Y, Fujisawa T, Kuniya T, Takagawa S, Muschler GF, Saito T. Low-intensity pulsed ultrasound accelerates fracture healing by stimulation of recruitment of both local and circulating osteogenic progenitors. J Orthop Res. 2012 Sep;30(9):1516-21. doi: 10.1002/jor.22103.
Shinohara K, Greenfield S, Pan H, Vasanji A, Kumagai K, Midura RJ, Kiedrowski M, Penn MS, Muschler GF. Stromal cell-derived factor-1 and monocyte chemotactic protein-3 improve recruitment of osteogenic cells into sites of musculoskeletal repair. J Orthop Res. 2011 Jul;29(7):1064-9. doi: 10.1002/jor.21374.
Pollak AN, Ficke CJ; Extremity War Injuries IV Session Moderators. Extremity war injuries: collaborative efforts in research, host nation care, and disaster preparedness. J Am Acad Orthop Surg. 2010 Jan;18(1):3-9. doi: 10.5435/00124635-201001000-00002.
Muschler GF, Raut VP, Patterson TE, Wenke JC, Hollinger JO. The design and use of animal models for translational research in bone tissue engineering and regenerative medicine. Tissue Eng Part B Rev. 2010 Feb;16(1):123-45. doi: 10.1089/ten.TEB.2009.0658.
McLain RF, Boehm CA, Rufo-Smith C, Muschler GF. Transpedicular aspiration of osteoprogenitor cells from the vertebral body: progenitor cell concentrations affected by serial aspiration. Spine J. 2009 Dec;9(12):995-1002. doi: 10.1016/j.spinee.2009.08.455.
Marcantonio NA, Boehm CA, Rozic RJ, Au A, Wells A, Muschler GF, Griffith LG. The influence of tethered epidermal growth factor on connective tissue progenitor colony formation. Biomaterials. 2009 Sep;30(27):4629-38. doi: 10.1016/j.biomaterials.2009.05.061.
Kim EJ, Boehm CA, Mata A, Fleischman AJ, Muschler GF, Roy S. Post microtextures accelerate cell proliferation and osteogenesis. Acta Biomater. 2010 Jan;6(1):160-9. doi: 10.1016/j.actbio.2009.06.016.
Mata A, Kim EJ, Boehm CA, Fleischman AJ, Muschler GF, Roy S. A three-dimensional scaffold with precise micro-architecture and surface micro-textures. Biomaterials. 2009 Sep;30(27):4610-7. doi: 10.1016/j.biomaterials.2009.05.023.
Kim EJ, Boehm CA, Fleischman AJ, Muschler GF, Kostov YV, Roy S. Modulating human connective tissue progenitor cell behavior on cellulose acetate scaffolds by surface microtextures. J Biomed Mater Res A. 2009 Sep 15;90(4):1198-205. doi: 10.1002/jbm.a.32160.
Villarruel SM, Boehm CA, Pennington M, Bryan JA, Powell KA, Muschler GF. The effect of oxygen tension on the in vitro assay of human osteoblastic connective tissue progenitor cells. J Orthop Res. 2008 Oct;26(10):1390-7. doi: 10.1002/jor.20666.
Patterson TE, Kumagai K, Griffith L, Muschler GF. Cellular strategies for enhancement of fracture repair. J Bone Joint Surg Am. 2008 Feb;90 Suppl 1:111-9. doi: 10.2106/JBJS.G.01572.
Mata A, Boehm C, Fleischman AJ, Muschler GF, Roy S. Connective tissue progenitor cell growth characteristics on textured substrates. Int J Nanomedicine. 2007;2(3):389-406.
Kumagai K, Vasanji A, Drazba JA, Butler RS, Muschler GF. Circulating cells with osteogenic potential are physiologically mobilized into the fracture healing site in the parabiotic mice model. J Orthop Res. 2008 Feb;26(2):165-75. doi: 10.1002/jor.20477.
Takigami H, Kumagai K, Latson L, Togawa D, Bauer T, Powell K, Butler RS, Muschler GF. Bone formation following OP-1 implantation is improved by addition of autogenous bone marrow cells in a canine femur defect model. J Orthop Res. 2007 Oct;25(10):1333-42. doi: 10.1002/jor.20411.
Powell KA, Nakamoto C, Villarruel S, Boehm C, Muschler G. Quantitative image analysis of connective tissue progenitors. Anal Quant Cytol Histol. 2007 Apr;29(2):112-21.
Lietman SA, Barsoum WK, Goldblum JR, Marks KE, Mascha E, Sundaram M, Muschler G. A 20-year retrospective review of surgically treated liposarcoma at the Cleveland Clinic. Orthopedics. 2007 Mar;30(3):227-34. doi: 10.3928/01477447-20070301-01.
Au A, Boehm CA, Mayes AM, Muschler GF, Griffith LG. Formation of osteogenic colonies on well-defined adhesion peptides by freshly isolated human marrow cells. Biomaterials. 2007 Apr;28(10):1847-61. doi: 10.1016/j.biomaterials.2006.12.009.
Mata A, Boehm C, Fleischman AJ, Muschler G, Roy S. Analysis of connective tissue progenitor cell behavior on polydimethylsiloxane smooth and channel micro-textures. Biomed Microdevices. 2002 Dec;4(4):267-75. doi: 10.1023/a:1020950022074.
Bidula J, Boehm C, Powell K, Barsoum W, Nakamoto C, Mascha E, Muschler GF. Osteogenic progenitors in bone marrow aspirates from smokers and nonsmokers. Clin Orthop Relat Res. 2006 Jan;442:252-9. doi: 10.1097/01.blo.0000183738.43245.c2.
McLain RF, Fleming JE, Boehm CA, Muschler GF. Aspiration of osteoprogenitor cells for augmenting spinal fusion: comparison of progenitor cell concentrations from the vertebral body and iliac crest. J Bone Joint Surg Am. 2005 Dec;87(12):2655-61. doi: 10.2106/JBJS.E.00230.
Muschler GF, Matsukura Y, Nitto H, Boehm CA, Valdevit AD, Kambic HE, Davros WJ, Easley KA, Powell KA. Selective retention of bone marrow-derived cells to enhance spinal fusion. Clin Orthop Relat Res. 2005 Mar;(432):242-51. doi: 10.1097/01.blo.0000149812.32857.8b.
Muschler GF, Nakamoto C, Griffith LG. Engineering principles of clinical cell-based tissue engineering. J Bone Joint Surg Am. 2004 Jul;86(7):1541-58. doi: 10.2106/00004623-200407000-00029.
Muschler GF, Midura RJ, Nakamoto C. Practical Modeling Concepts for Connective Tissue Stem Cell and Progenitor Compartment Kinetics. J Biomed Biotechnol. 2003;2003(3):170-193. doi: 10.1155/S1110724303209165.
Muschler GF, Nitto H, Matsukura Y, Boehm C, Valdevit A, Kambic H, Davros W, Powell K, Easley K. Spine fusion using cell matrix composites enriched in bone marrow-derived cells. Clin Orthop Relat Res. 2003 Feb;(407):102-18. doi: 10.1097/00003086-200302000-00018.
Mata A, Boehm C, Fleischman AJ, Muschler G, Roy S. Growth of connective tissue progenitor cells on microtextured polydimethylsiloxane surfaces. J Biomed Mater Res. 2002 Dec 15;62(4):499-506. doi: 10.1002/jbm.10353.
Anderson ME, Hyodo A, Zehr RJ, Marks KE, Muschler GF. Abductor reattachment with a custom proximal femoral replacement prosthesis. Orthopedics. 2002 Jul;25(7):722-6.
Muschler GF, Midura RJ. Connective tissue progenitors: practical concepts for clinical applications. Clin Orthop Relat Res. 2002 Feb;(395):66-80. doi: 10.1097/00003086-200202000-00008.
Patents
| US Patent | Patent Title | Issue Date | First-Named Inventor |
|---|---|---|---|
| 8,068,670 | Image Analysis of Biological Objects | 11/29/2011 | George F. Muschler, MD |
| 7,796,815 | Image Analysis of Biological Objects | 09/14/2010 | George F. Muschler, MD |
| 5,626,579 | Bone Transport and Lengthening System | 04/07/1997 | George F. Muschler, MD |
| 5,429,638 | Bone Transport and Lengthening System | 07/04/1995 | George F. Muschler, MD |