Xiaojuan Li Laboratory

Research

My team’s multidisciplinary research focuses on developing advanced imaging and image processing techniques to improve early diagnosis and treatment for significant musculoskeletal diseases, including osteoarthritis, inflammatory arthritis, sports injury, and osteoporosis.

We develop sophisticated quantitative magnetic resonance (MRI) and magnetic resonance spectroscopic (MRSI) imaging techniques (new pulse sequences, fast imaging with novel reconstruction) and image‑/data‑processing methodologies. These techniques enable us to: 1) detect early cartilage degeneration and inflammation-related abnormalities/lesions; 2) quantify bone shapes; 3) link MRI and nuclear magnetic resonance (NMR) measures with molecular activities in tissues; 4) quantify bone marrow adiposity, and; 5) explore the relationship with bone quantity/quality.

We have also begun performing research in applying machine-learning/deep-learning techniques for novel reconstruction of accelerated MRI acquisition, automatic tissue segmentation and lesion detection, and automatic diagnostic grading and prediction of patient outcomes.

I am also founding director of the collaborative Program in Advanced Medical Imaging (PAMI), with Carl S. Winalski, MD, Diagnostic Radiology, as Clinical Director. PAMI brings together a number of disciplines, within and outside Cleveland Clinic, to advance musculoskeletal imaging for orthopaedics and rheumatology through technology development, translational research, and education. We aim to establish the PAMI center as a robust global resource for musculoskeletal imaging-based research.

Selected Publications

1. Desai AD, Caliva F, Iriondo C, Khosravan N, Mortazi A, Jambawalikar S, Torigian D, Ellerman J, Akcakaya M, Bagci U, Tibrewala R, Flament I, O’Brian M, Majumdar S, Perslev M, Pai A, Igel C, Dam EB, Gaj S, Yang M, Nakamura K, Li X, Deniz CM, Juras V, Regatte R, Gold GE, Hargreaves BA, Pedoia B, Chaudhari AS. The International Workshop on Osteoarthritis Imaging Knee MRI Segmentation Challenge: A Multi-Institute Evaluation and Analysis Framework on a Standardized Dataset, Radiology AI, in press.
2. Kim J, Mamoto K, Lartey R, Xu K, Nakamura K, Shin W, Winalski CS, Obuchowski N, Tanaka M, Bahroos E, Link TM, Hardy P, Peng Q, Reddy R, Bemden AB, Liu K, Peters RD, Wu C, Li X, Multivendor multisite T1rho and T2 quantification of knee cartilage, Osteoarthritis and Cartilage, 2020 Dec;28(12):1539-1550. doi: 10.1016/j.joca.2020.07.005.Epub 2020 Jul 30.
3. Gaj S, Yang M, Nakamura K, Li X. Automated cartilage and meniscus segmentation of knee MRI with conditional generative adversarial networks. Magn Reson Med. 2020;84(1):437-49. Epub 2019/12/04. doi: 10.1002/mrm.28111. PubMed PMID: 31793071.
4. Guimaraes JB, Schwaiger BJ, Gersing AS, Neumann J, Facchetti L, Li X, Joseph GB, Link TM, Meniscal Ramp Lesions: Frequency, Natural History and the Effect on Knee Cartilage over 2 Years in Subjects with Anterior Cruciate Ligament Tears, Skeletal Radiology, 2021 Mar;50(3):551-558. doi: 10.1007/s00256-020-03596-5. Epub 2020 Sep 8.
5. Oak SR, Cantrell WA, Altahawi F, Li X, Winalski CS, Flanigan DC, Reinke EK, Huston LJ, Jones MH, Spindler KP, Do Bone-Patellar Tendon-Bone ACL Reconstructed Knees have more MRI signs of Patellofemoral Post-Traumatic Osteoarthritis than their Uninjured Contralateral Knee at 2 Years? Orthop J Sports Med, 2021 Jan 12;9(1):2325967120973050. doi: 10.1177/2325967120973050.eCollection 2021 Jan.
6. Friedman JM, Su F, Zhang AL, Allen CR, Feeley BT, Souza R, Li X, Ma CB, Lansdown DA, Patient Reported Activity Levels Correlate with Early Cartilage Degeneration after Anterior Cruciate Ligament Reconstruction Am J Sports Med. 2021 Jan 4;363546520980431. doi: 10.1177/0363546520980431.Online ahead of print.
7. Finzel S, Manske SL, Barnabe CC, Burghardt AJ, Marotte H, Scharmga A, Hauge EM, Chapurlat R, Engelke K, Li X, Teeffelen B, Conaghan PG, Stok KS, Reliability and Change in Erosion Measurements by High-Resolution peripheral Quantitative Computed Tomography in a Longitudinal Dataset of Rheumatoid Arthritis Patients.J Rheumatol. 2020 Sep 15;jrheum.191391. doi: 10.3899/jrheum.191391. Online ahead of print.
8. Subhas N, Li H, Yang M, Winalski CS, Polster J, Obuchowski N, Mamoto K, Liu R, Zhang C, Huang P, Gaire SK, Liang D, Shen B, Li X, Ying L. Diagnostic interchangeability of deep convolutional neural networks reconstructed knee MR images: preliminary experience. Quant Imaging Med Surg 2020 Sep;10(9):1748-1762. doi: 10.21037/qims-20-664.
9. Orozco GA, Bolcos P, Mohammadi A, Tanaka MS, Yang M, Link TM, Ma CB, Li X, Tanska P, Korhonen RK, Prediction of local fixed charge density loss in cartilage following ACL injury and reconstruction: a computational proof-of-concept study with MRI, J Orthop Res. 2020 Jul 8;10.1002/jor.24797. doi: 10.1002/jor.24797. Online ahead of print.
10. Lansdown DA, Xiao W, Zhang AL, Allen CR, Feeley BT, Li X, Majumdar S, Ma CB. Quantitative imaging of anterior cruciate ligament (ACL) graft demonstrates longitudinal compositional changes and relationships with clinical outcomes at 2 years after ACL reconstruction. J Orthop Res. 2020 Jun;38(6):1289-1295. doi: 10.1002/jor.24572. Epub 2020 Jan 5.
11. Li AK, Ochoa JK, Pedoia V, Amano K, Souza RB, Li X, Ma CB, Altered Tibiofemoral Position Following ACL Reconstruction is Associated with Cartilage Matrix Changes: A Voxel Based Relaxometry Analysis, J Ortho Res 2020 May 5. doi: 10.1002/jor.24708. Online ahead of print.
12. Li AK, Pedoia V, Tanaka M, Souza RB, Ma CB, Li X. Six month post-surgical elevations in cartilage T1rho relaxation times are associated with functional performance 2 years after ACL reconstruction. J Orthop Res. 2020 May;38(5):1132-1140. doi: 10.1002/jor.24544. Epub 2019 Dec 11.
13. Shimizu T, Markes AR, Samaan MA, Tanaka MS, Souza RB, Li X, Ma CB. Patients with Abnormal Limb Kinetics at 6 Months After Anterior Cruciate Ligament Reconstruction Have an Increased Risk of Persistent Medial Meniscal Abnormality at 3 Years. Orthopaedic journal of sports medicine. 2020;8(1):2325967119895248. Epub 2020/02/08. doi: 10.1177/2325967119895248. PubMed PMID: 32030346; PMCID: PMC6978828.
14. Li X, Schwartz AV. MRI Assessment of Bone Marrow Composition in Osteoporosis. Curr Osteoporos Rep. 2020 Feb;18(1):57-66. doi: 10.1007/s11914-020-00562-x.
15. Woods GN, Ewing SK, Sigurdsson S, Kado DM, Eiriksdottir G, Gudnason V, Hue TF, Lang TF, Vittinghoff E, Harris TB, Rosen C, Xu K, Li X, Schwartz AV. Greater Bone Marrow Adiposity Predicts Bone Loss in Older Women. J Bone Miner Res. 2020 Feb;35(2):326-332. doi: 10.1002/jbmr.3895. Epub 2019 Nov 14.
16. Stok KS, Burghardt AJ, Boutroy S, Peters MPH, Manske SL, Stadelmann V, Vilayphiou N, van den Bergh JP, Geusens P, Li X,Marotte H, van Rietbergen B, Boyd SK, Barnabe C, SPECTRA Collaboration, Consensus approach for 3D joint space width of metacarpophalangeal joints of rheumatoid arthritis patients using high-resolution peripheral quantitative computed tomography, Quant Imaging Med Surg, 2020 Feb; 10(2):314-325. doi: 10.21037/qims.2019.12.11.
17. Beckford-Vera DR, Gonzalez-Junca A, Janneck JS, Huynh TL, Blecha JE, Seo Y, Li X, VanBrocklin VF, Franc BL, PET/CT imaging of human TNFα using 89Zr-certolizumab pegol in a transgenic preclinical model of rheumatoid arthritis, Molecular Imaging and Biology, Mol Imaging Biol 2020 Feb;22(1):105-114. doi: 10.1007/s11307-019-01363-0
18. Shimizu T, Cheng Z, Samann MA, Tanaka MS, Souza RB, Li X, Ma CB, Increases in Joint Laxity After Anterior Cruciate Ligament Reconstruction Are Associated With Sagittal Biomechanical Asymmetry, Arthroscopy, 35(7):2072-2079. doi: 10.1016/j.arthro.2019.01.050. Epub 2019 Jun 18.
19. Heilmeier U, Mamoto K, Amano K, Eck B, Tanaka M, Bullen JA, Schwaiger BJ, Huebner JL, Stabler TV, Kraus VB, Ma CB, Link TM, Li X, Infrapatellar fat pad abnormalities are associated with a higher inflammatory synovial fluid cytokine profile and may have a potential role in the development of posttraumatic OA following ACL tears, Osteoarthritis Cartilage 2019 Sep 14. pii: S1063-4584(19)31206-3. doi: 10.1016/j.joca.2019.09.001. [Epub ahead of print]
20. Bolcos PO, Mononen ME, Tanaka MS, Yang M, Suomalainen JS, Nissi MJ, Töyräs J, Ma B, Li X, Korhonen RK, Identification of locations susceptible to osteoarthritis in patients with anterior cruciate ligament reconstruction: Combining knee joint computational modelling with follow-up T1ρ and T2 imaging, Clin Biomech (Bristol, Avon). 2019 Aug 9. pii: S0268-0033(18)31029-5. doi: 10.1016/j.clinbiomech.2019.08.004. [Epub ahead of print]
21. Keenan KE, Biller JR, Delfino JG, Boss MA, Does MD, Evelhoch JL, Griswold MA, Gunter JL, Hinks RS, Hoffman SW, Kim G, Lattanzi R, Li X, Marinelli L, Metzger GJ, Mukherjee P, Nordstrom RJ, Peskin AP, Perez E, Russek SE, Sahiner B, Serkova N, Shukla-Dave A, Steckner M, Stupic KF, Wilmes LJ, Wu HH, Zhang H, Jackson EF, Sullivan DC, Recommendations towards standards for quantitative MRI (qMRI) and outstanding needs, J Magn Reson Imaging. 2019 Jun;49(7):e26-e39. doi: 10.1002/jmri.26598. Epub 2019 Jan 24.
22. Zhong Q, Pedoia V, Tanaka M, Neumann J, Link TM, Ma CB, Lin J, Li X, 3D Bone-shape changes and their correlations with cartilage T1ρ and T2 relaxation times and patient-reported outcomes over 3-years after ACL reconstruction, Osteoarthritis Cartilage. 2019 Jun;27(6):915-921. doi: 10.1016/j.joca.2019.01.017. Epub 2019 Feb 23.
23. Li X, Roemer FW, Compositional changes predict morphologic cartilage lesion development - are we one step closer to clinical translation of quantitative MRI? Osteoarthritis Cartilage. 2019 May;27(5):723-725. doi: 10.1016/j.joca.2019.01.014.Epub 2019 Feb 6.
24. Wan C, Ge L, Souza RB, Tang SY, Alliston T, Hao Z, Li X, T1ρ-based fibril-reinforced poroviscoelastic constitutive relation of human articular cartilage using inverse finite element technology, Quant Imaging Med Surg 2019 Mar;9(3):359-370. doi: 10.21037/qims.2019.03.01.
25. Markes AR, Knox J, Zhong Q, Pedoia V, Li X, Ma CB, An Abnormal Tibial Position Is Associated With Alterations in the Meniscal Matrix: A 3-Year Longitudinal Study After Anterior Cruciate Ligament Reconstruction. Orthop J Sports Med. 2019 Jan 10;7(1):2325967118820057. doi: 10.1177/2325967118820057. eCollection 2019 Jan.
26. Woods GN, Ewing SK, Sigurdsson S, Kado DM, Ix JH, Hue TF, Eiriksdottir G, Xu K, Gudnason V, Lang TF, Vittinghoff E, Harris TB, Rosen CJ, Li X, Schwartz AV. Chronic Kidney Disease Is Associated With Greater Bone Marrow Adiposity. J Bone Miner Res. 2018 Dec;33(12):2158-2164. doi: 10.1002/jbmr.3562. Epub 2018 Aug 27.
27. Bolcos PO, Mononen ME, Mohammadi A, Ebrahimi M, Tanaka MS, Samaan MA, Souza RB, Li X, Suomalainen JS, Jurvelin JS, Töyräs J, Korhonen RK, Comparison between kinetic and kinetic-kinematic driven knee joint finite element models. Sci Rep. 2018 Nov 26;8(1):17351. doi: 10.1038/s41598-018-35628-5.
28. Chen E, Amano K, Pedoia V, Souza RB, Ma CB, Li X, Longitudinal analysis of tibiofemoral cartilage contact area and position in ACL reconstructed patients. J Orthop Res. 2018 Oct;36(10):2718-2727. doi: 10.1002/jor.24024. Epub 2018 Jun 13.
29. Link TM, Li X, Establishing compositional MRI of cartilage as a biomarker for clinical practice, Osteoarthritis Cartilage. 2018 Sep;26(9):1137-1139. doi: 10.1016/j.joca.2018.02.902. Epub 2018 Mar 15.
30. Guimaraes JB, Facchetti L, Schwaiger BJ, Gersing A, Li X, Link TM, Natural Evolution of Popliteomeniscal Fascicle Tears over Two Years and its Association with Lateral Articular Knee Cartilage Degeneration in Patients with Traumatic Anterior Cruciate Ligament Tear. Eur Radiol. 2018 Aug;28(8):3542-3549. doi: 10.1007/s00330-017-5279-9. Epub 2018 Feb 23.
31. Knox J, Pedoia V, Wang A, Tanaka M, Joseph GB, Neumann J, Link TM, Li X, Ma CB, Longitudinal changes in MR T1p/T2 signal of meniscus and its association with cartilage T1p/T2 in ACL-injured patients. Osteoarthritis Cartilage. 2018 May;26(5):689-696. doi: 10.1016/j.joca.2018.02.001. Epub 2018 Feb 10.
32. Amano K, Huebner JL, Stabler TV, Tanaka M, McCulloch CE, Lobach I, Lane NE, Kraus VB, Ma CB, Li X, Synovial fluid profile at the time of ACL reconstruction and its association with cartilage matrix composition 3 years after surgery, Am J Sports Med, 2018 Mar;46(4):890-899. doi: 10.1177/0363546517749834. Epub 2018 Jan 24. PMID: 29364702
33. Mistry SD, Woods GN, Sigurdsson S, Ewing SK, Hue TF, Eiriksdottir G, Xu K, Hilton JF, Kado DM, Gudnason V, Harris TB, Rosen CJ, Lang TF, Li X, Schwartz AV, Sex hormones are negatively associated with vertebral bone marrow fat, BONE, 2018 Mar;108:20-24. doi: 10.1016/j.bone.2017.12.009. Epub 2017 Dec 11.
34. Xu K, Sigurdsson S, Gudnason V, Hue T, Schwartz AV, Li X, Reliable Quantification of Marrow Fat Content and Unsaturation Level Using in Vivo MR Spectroscopy, Magnetic Resonance in Medicine, 2018 Mar;79(3):1722-1729. doi: 10.1002/mrm.26828. Epub 2017 Jul 16. PMID: 28714169
35. Kumar D, Su F, Daniel W, Pedoia V, Heitkamp L, Ma CB, Souza RB, Li X, Frontal plane knee mechanics and early cartilage degeneration in people with ACL reconstruction: A longitudinal study, American Journal of Sports Medicine, 2018 Feb;46(2):378-387. doi: 10.1177/0363546517739605. Epub 2017 Nov 10.
36. Azus A, Teng HL, Tufts L, Wu D, Ma CB, Souza R, Li X, Biomechanical Factors Associate with Pain and Symptoms Following Anterior Cruciate Ligament Injury and Reconstruction, The Journal of Injury, Function and Rehabilitation, 2018 Jan;10(1):56-63. doi: 10.1016/j.pmrj.2017.05.004. Epub 2017 Jun 8
37. Teng HL, Wu D, Su F, Pedoia V, Asuz AR, Souza RB, Ma CB, Li X, Gait Characteristics Associated with Greater Increase in Medial Knee Cartilage T1rho and T2 Relaxation Times in Individuals with Anterior Cruciate Ligament Reconstruction, Am J Sports Med 2017 Dec;45(14):3262-3271. doi: 10.1177/0363546517723007. Epub 2017 Sep 12.
38. Kim TY, Schwartz AV, Li X, Xu K, Black DM, Petrenko DM, Stewart L, Rogers SJ, Posselt AM, Carter JT, Shoback DM, Schafer AL, Bone marrow fat changes after gastric bypass surgery are associated with loss of bone mass, J Bone Miner Res 2017 Nov;32(11):2239-2247. doi: 10.1002/jbmr.3212. Epub 2017 Aug 9
39. Lansdown DA, Pedoia V, Zaid M, Amano K, Souza RB, Li X, Ma CB, Variations in Knee Kinematics Following ACL Injury and After Reconstruction Are Correlated with Bone Shape Differences, Clinical Orthopaedics and Related Research, 2017 Oct;475(10):2427-2435. doi: 10.1007/s11999-017-5368-8.
40. Samaan MA, Facchetti L, Pedoia V, Tanaka MS, Link TM, Souza RB, Ma CB, Li X, Cyclops lesions are associated with altered gait patterns and medial knee joint cartilage degeneration at 1 year after ACL-reconstruction. J Orthop Res 2017 Oct;35(10):2275-2281. doi: 10.1002/jor.23530. Epub 2017 Feb 10.
41. Shimizu T, Choi HJ, Heilmeier U, Tanaka M, Burghardt AJ, Gong J, Chanchek N, Link TM, Graf J, Imboden JB, Li X, Assessment of 3-month changes in bone microstructure under anti-TNFa therapy in patients with rheumatoid arthritis using high-resooution peripheral quantitative computed tomography (HR-pQCT, Arthritis Res Ther. 2017 Oct 4;19(1):222. doi: 10.1186/s13075-017-1430-x.
42. Li X, Shet K, Xu K, Rodriguez JP, Pino AM, Kurhanewicz J, Schwartz A, Rosen CJ, Unsaturation level decreased in bone marrow fat of postmenopausal women with low bone density using high resolution magic angle spinning (HRMAS) 1H NMR spectroscopy, Bone, 2017 Aug 18;105:87-92. doi: 10.1016/j.bone.2017.08.014. [Epub ahead of print]
43. Facchetti L, Schwaiger BJ, Gersing AS, Guimaraes JB, Nardo L, Majumdar S, Ma BC, Link TM, Li X, UCSF-P50_ACL Consortium, Cyclops lesions detected by MRI are frequent findings after ACL surgical reconstruction but do not impact clinical outcome over 2 years, Eur Radiol. 2017 Aug;27(8):3499-3508. doi: 10.1007/s00330-016-4661-3. Epub 2016 Dec 16.
44. Su F, Pedoia V, Teng HL, Kretzschmar M, Lau BC, McCulloch CE, Link TM, Ma CB, Li X. The association between MR T1rho and T2 of cartilage and patient-reported outcomes after ACL injury and reconstruction. Osteoarthritis Cartilage. 2016 Jul; 24(7):1180-9. PMID: 26850823
45. Tufts LS, Shet K, Liang F, Majumdar S, Li X. Quantification of bone marrow water and lipid composition in anterior cruciate ligament-injured and osteoarthritic knees using three-dimensional magnetic resonance spectroscopic imaging. Magn Reson Imaging. 2016 Jun; 34(5):632-7. PMID: 26723848
46. Ku E, Pedoia V, Tanaka M, Imboden J, Graf J, Link TM, Li X, Evaluating Radiocarpal Cartilage Matrix changes 3-months after anti-TNF treatment for Rheumatoid Arthritis using MR T1ρ Imaging, J Magn Reson Imag, 2017 May;45(5):1514-1522. doi: 10.1002/jmri.25448. Epub 2016 Sep 23.
47. Amano K, Pedoia V, Su F, Souza RB, Li X, Ma CB, Persistent Biomechanical Alterations After ACL Reconstruction Are Associated With Early Cartilage Matrix Changes Detected by Quantitative MR Orthop J Sports Med. 2016 Apr 28;4(4):2325967116644421. doi: 10.1177/2325967116644421.
48. Link TM, Neumann J, Li X, Prestructural Cartliage Assessment, J Magn Reson Imag, 2017 Apr;45(4):949-965. doi: 10.1002/jmri.25554. Epub 2016 Dec 26.
49. Sheu Y, Amati F, Schwartz AV, Danielson ME, Lee CG, Bauer DC, Li X, Goodpaster BH, Cauley JA, Vertebral bone marrow fat, bone mineral density and diabetes: The Osteoporotic fractures in Men (MrOS) study. Bone. 2017 Apr;97:299-305. doi: 10.1016/j.bone.2017.02.001. Epub 2017 Feb 4.
50. Amano K, Li AK, Pedoia V, Koff MF, Krych AJ, Link TM, Potter H, Rodeo S, Li X, Ma CB, Majumdar S, Effects of surgical factors on cartilage can be detected using quantitative magnetic resonance imaging after ACL reconstruction, American Journal of Sports Medicine, 2017 Apr;45(5):1075-1084. doi: 10.1177/0363546516677794. Epub 2017 Jan 27.
51. Pedoia V, Su F, Amano K, Li Q, McCulloch CB, Souza RB, Link TM, Ma CB, Li X, Analysis of the Articular Cartilage T1ρ And T2Relaxation Times Changes After ACL Reconstruction in Injured and Contralateral Knees and Relationships with Bone Shape, J. Ortho Research (JOR), 2017 Mar;35(3):707-717. doi: 10.1002/jor.23398. Epub 2016 Sep 19.
52. Yang H, Yu A, Burghardt AJ, Virayavanich W, Link TM, Imboden JB, Li X. Quantitative characterization of metacarpal and radial bone in rheumatoid arthritis using high resolution- peripheral quantitative computed tomography. Int J Rheum Dis. 2017 Mar;20(3):353-362. doi: 10.1111/1756-185X.12558. Epub 2015 Apr 10.
53. Brandao Guimaraes J, Facchetti L, Schwaiger BJ, Gersing AS, Majumdar S, Ma CB, Li X, Link TM, UCSF-P50-ACL Consortium, Evolution of Intrameniscal Signal Alterations Detected by MRI over 24 months in Patients with Traumatic Anterior Cruciate Ligament Tear, AJR Am J Roentgenol. 2017 Feb;208(2):386-392. doi: 10.2214/AJR.16.16625. Epub 2016 Nov 8.
54. Franc BL, Goth S, MacKenzie J, Li X, Blecha J, Lam T, Jiva S, Hawkins RA, VanBrocklin H, In Vivo PET Imaging of the Activated Immune Environment in a small animal Model of Inflammatory Arthritis, Molecular Imaging, 16: 1-9, 2017 Jan, DOI: 10.1177/1536012117712638
55. Pedoia V, Russell C, Randolph A, Li X, Majumdar S, PCA-T1ρ Voxel Based Relaxometry of the Articular Cartilage: a Comparison of Biochemical Patterns in Osteoarthritis and ACL subjects, Quantitative Imaging in Medicine and Surgery, 2016 Dec;6(6):623-633. doi: 10.21037/qims.2016.11.03.
56. Gong J, Pedoia V, Facchetti L, Link TM, Ma CB, Li X, Bone marrow edema-like lesions (BMELs) are associated with higher T1ρ and T2 values of cartilage in anterior cruciate ligament (ACL)-reconstructed knees: a longitudinal study, Quant Imaging Med Surg. 2016 Dec;6(6):661-670. doi: 10.21037/qims.2016.12.11.
57. Pedoia V, Li X, Su F, Calixto N, Majumdar S. Fully automatic analysis of the knee articular cartilage T1? relaxation time using voxel-based relaxometry. J Magn Reson Imaging. 2016 Apr; 43(4):970-80. PMID: 26443990
58. Wang A, Pedoia V, Su F, Abramson E, Kretzschmar M, Nardo L, Link TM, McCulloch CE, Jin C, Ma CB, Li X. MR T1rho and T2 of meniscus after acute anterior cruciate ligament injuries. Osteoarthritis Cartilage. 2016 Apr; 24(4):631-9. PMID: 26620091
59. Zhou Y, Pandit P, Pedoia V, Rivoire J, Wang Y, Liang D, Li X, Ying L. Accelerating t1? cartilage imaging using compressed sensing with iterative locally adapted support detection and JSENSE. Magn Reson Med. 2016 Apr; 75(4):1617-29. PMID: 26010735
60. Pandit P, Rivoire J, King K, Li X. Accelerated T1rho acquisition for knee cartilage quantification using compressed sensing and data-driven parallel imaging: A feasibility study. Magn Reson Med. 2016 Mar; 75(3):1256-61. PMID: 25885368
61. Calixto NE, Kumar D, Subburaj K, Singh J, Schooler J, Nardo L, Li X, Souza RB, Link TM, Majumdar S. Zonal differences in meniscus MR relaxation times in response to in vivo static loading in knee osteoarthritis. J Orthop Res. 2016 Feb; 34(2):249-61. PMID: 26223430
62. Liu J, Pedoia V, Heilmeier U, Ku E, Su F, Khanna S, Imboden J, Graf J, Link T, Li X. High-temporospatial-resolution dynamic contrast-enhanced (DCE) wrist MRI with variable-density pseudo-random circular Cartesian undersampling (CIRCUS) acquisition: evaluation of perfusion in rheumatoid arthritis patients. NMR Biomed. 2016 Jan; 29(1):15-23. PMID: 26608949
63. Wang YX, Zhang Q, Li X, Chen W, Ahuja A, Yuan J, T1ρ magnetic resonance: basic physics principles and applications in knee and intervertebral disc imaging, Quant Imaging Med Surg, 2015 Dec;5(6):858-85. doi: 10.3978/j.issn.2223-4292.2015.12.06.
64. Lansdown DA, Allen C, Zaid M, Wu S, Subburaj K, Souza R, Feeley BT, Li X, Ma CB. A comprehensive in vivo kinematic, quantitative MRI and functional evaluation following ACL reconstruction - A comparison between mini-two incision and anteromedial portal femoral tunnel drilling. Knee. 2015 Dec; 22(6):547-53. PMID: 25982298
65. Pedoia V, Lansdown DA, Zaid M, McCulloch CE, Souza R, Ma CB, Li X. Three-dimensional MRI-based statistical shape model and application to a cohort of knees with acute ACL injury. Osteoarthritis Cartilage. 2015 Oct; 23(10):1695-703. PMID: 26050865
66. Kumar D, Souza RB, Subburaj K, MacLeod TD, Singh J, Calixto NE, Nardo L, Link TM, Li X, Lane NE, Majumdar S. Are There Sex Differences in Knee Cartilage Composition and Walking Mechanics in Healthy and Osteoarthritis Populations? Clin Orthop Relat Res. 2015 Aug; 473(8):2548-58. PMID: 25716211.
67. Zaid M, Lansdown D, Su F, Pedoia V, Tufts L, Rizzo S, Souza RB, Li X, Ma CB. Abnormal tibial position is correlated to early degenerative changes one year following ACL reconstruction. J Orthop Res. 2015 Jul; 33(7):1079-86. PMID: 25721417
68. Lansdown DA, Zaid M, Pedoia V, Subburaj K, Souza R, Benjamin C, Li X. Reproducibility measurements of three methods for calculating in vivo MR-based knee kinematics. J Magn Reson Imaging. 2015 Aug; 42(2):533-8. PMID: 25545617
69. Li X, Pedoia V, Kumar D, Rivoire J, Wyatt C, Lansdown D, Amano K, Okazaki N, Savic D, Koff MF, Felmlee J, Williams SL, Majumdar S. Cartilage T1rho and T2 relaxation times: Longitudinal reproducibility and variations using different coils, MR systems and sites. Osteoarthritis Cartilage. 2015 Jul 14. PMID: 26187574.
70. Lee CH, Srikhum W, Burghardt AJ, Virayavanich W, Imboden JB, Link TM, Li X. Correlation of structural abnormalities of the wrist and metacarpophalangeal joints evaluated by high-resolution peripheral quantitative computed tomography, 3 Tesla magnetic resonance imaging and conventional radiographs in rheumatoid arthritis. Int J Rheum Dis. 2015 Jul; 18(6):628-39. PMID: 25293500
71. Schafer AL, Li X, Schwartz AV, Tufts LS, Wheeler AL, Grunfeld C, Stewart L, Rogers SJ, Carter JT, Posselt AM, Black DM, Shoback DM. Changes in vertebral bone marrow fat and bone mass after gastric bypass surgery: A pilot study. Bone. 2015 May; 74:140-5. PMID: 25603463
72. Tufts L, Shet Vishnudas K, Fu E, Kurhanewicz J, Ries M, Alliston T, Li X. Correlating high-resolution magic angle spinning NMR spectroscopy and gene analysis in osteoarthritic cartilage. NMR Biomed. 2015 May; 28(5):523-8. PMID: 25761416
73. Subburaj K, Souza RB, Wyman BT, Le Graverand-Gastineau MP, Li X, Link TM, Majumdar S. Changes in MR relaxation times of the meniscus with acute loading: an in vivo pilot study in knee osteoarthritis. J Magn Reson Imaging. 2015 Feb; 41(2):536-43. PMID: 24347310
74. Li X, Wyatt C, Rivoire J, Han E, Chen W, Schooler J, Liang F, Shet K, Souza R, Majumdar S. Simultaneous acquisition of T1? and T2 quantification in knee cartilage: repeatability and diurnal variation. J Magn Reson Imaging. 2014 May; 39(5):1287-93. PMID: 23897756
75. Theologis AA, Haughom B, Liang F, Zhang Y, Majumdar S, Link TM, Ma CB, Li X. Comparison of T1rho relaxation times between ACL-reconstructed knees and contralateral uninjured knees. Knee Surg Sports Traumatol Arthrosc. 2014 Feb;22(2):298-307.
76. Schooler J, Kumar D, Nardo L, McCulloch C, Li X, Link TM, Majumdar S. Longitudinal evaluation of T1? and T2 spatial distribution in osteoarthritic and healthy medial knee cartilage. Osteoarthritis Cartilage. 2014 Jan; 22(1):51-62. PMID: 24188868
77. Kumar D, Karampinos DC, MacLeod TD, Lin W, Nardo L, Li X, Link TM, Majumdar S, Souza RB. Quadriceps intramuscular fat fraction rather than muscle size is associated with knee osteoarthritis. Osteoarthritis Cartilage. 2014 Feb; 22(2):226-34. PMID: 24361743
78. Souza RB, Kumar D, Calixto N, Singh J, Schooler J, Subburaj K, Li X, Link TM, Majumdar S. Response of knee cartilage T1rho and T2 relaxation times to in vivo mechanical loading in individuals with and without knee osteoarthritis. Osteoarthritis Cartilage. 2014 Oct; 22(10):1367-76. PMID: 24792208
79. Jungmann PM, Baum T, Bauer JS, Karampinos DC, Erdle B, Link TM, Li X, Trattnig S, Rummeny EJ, Woertler K, Welsch GH. Cartilage repair surgery: outcome evaluation by using noninvasive cartilage biomarkers based on quantitative MRI techniques? Biomed Res Int. 2014; 2014:840170. PMID: 24877139
80. Kumar D, Kothari A, Souza RB, Wu S, Benjamin Ma C, Li X. Frontal plane knee mechanics and medial cartilage MR relaxation times in individuals with ACL reconstruction: A pilot study. Knee. 2014 Oct; 21(5):881-5. PMID: 24993277
81. Teruel JR, Burghardt AJ, Rivoire J, Srikhum W, Noworolski SM, Link TM, Imboden JB, Li X. Bone structure and perfusion quantification of bone marrow edema pattern in the wrist of patients with rheumatoid arthritis: a multimodality study. J Rheumatol. 2014 Sep; 41(9):1766-73. PMID: 25086074
82. Gupta R, Virayavanich W, Kuo D, Su F, Link T, Ma B, Li X. MR T(1)rho quantification of cartilage focal lesions in acutely injured knees: correlation with arthroscopic evaluation. Magn Reson Imaging. 2014 Dec; 32(10):1290-6. PMID: 25111625
83. Kumar D, Souza RB, Singh J, Calixto NE, Nardo L, Link TM, Li X, Majumdar S. Physical activity and spatial differences in medial knee T1rho and t2 relaxation times in knee osteoarthritis. J Orthop Sports Phys Ther. 2014 Dec; 44(12):964-72. PMID: 25353261
84. Ma YH, Schwartz AV, Sigurdsson S, Hue TF, Lang TF, Harris TB, Rosen CJ, Vittinghoff E, Eiriksdottir G, Hauksdottir AM, Siggeirsdottir K, Sigurdsson G, Oskarsdottir D, Napoli N, Palermo L, Gudnason V, Li X. Circulating sclerostin associated with vertebral bone marrow fat in older men but not women. J Clin Endocrinol Metab. 2014 Dec; 99(12):E2584-90. PMID: 25144629
85. Li X, Majumdar S. Quantitative MRI of articular cartilage and its clinical applications. J Magn Reson Imaging. 2013 Nov; 38(5):991-1008. PMID: 24115571
86. Jobke B, Bolbos R, Saadat E, Cheng J, Li X, Majumdar S. Mechanism of disease in early osteoarthritis: application of modern MR imaging techniques - a technical report. Magn Reson Imaging. 2013 Jan; 31(1):156-61.
87. Schwartz AV, Sigurdsson S, Hue TF, Lang TF, Harris TB, Rosen CJ, Vittinghoff E, Siggeirsdottir K, Sigurdsson G, Oskarsdottir D, Shet K, Palermo L, Gudnason V, Li X. Vertebral bone marrow fat associated with lower trabecular BMD and prevalent vertebral fracture in older adults. J Clin Endocrinol Metab. 2013 Jun; 98(6):2294-300. PMID: 23553860
88. Srikhum W, Virayavanich W, Burghardt AJ, Yu A, Link TM, Imboden JB, Li X. Quantitative and Semiquantitative Bone Erosion Assessment on High-resolution Peripheral Quantitative Computed Tomography in Rheumatoid Arthritis. J Rheumatol. 2013 Apr;40(4):408-16. doi: 10.3899/jrheum.120780. Epub 2013 Feb 15..
89. Subburaj K, Valentinitsch A, Dillon AB, Joseph GB, Li X, Link TM, Vail TP, Majumdar S. Regional variations in MR relaxation of hip joint cartilage in subjects with and without femoralacetabular impingement. Magn Reson Imaging. 2013 Sep; 31(7):1129-36. PMID: 23684960
90. Kazakia GJ, Kuo D, Schooler J, Siddiqui S, Shanbhag S, Bernstein G, Horvai A, Majumdar S, Ries M, Li X. Bone and cartilage demonstrate changes localized to bone marrow edema-like lesions within osteoarthritic knees. Osteoarthritis Cartilage. 2013 Jan; 21(1):94-101.
91. Su F, Hilton JF, Nardo L, Wu S, Liang F, Link TM, Ma CB, Li X. Cartilage morphology and T1? and T2 quantification in ACL-reconstructed knees: a 2-year follow-up. Osteoarthritis Cartilage. 2013 Aug; 21(8):1058-67. PMID: 23707754
92. Kumar D, Schooler J, Zuo J, McCulloch CE, Nardo L, Link TM, Li X, Majumdar S. Trabecular bone structure and spatial differences in articular cartilage MRrelaxation times in individuals with posterior horn medial meniscal tears. Osteoarthritis Cartilage. 2013 Jan; 21(1):86-93.
93. Thuillier DU, Souza RB, Wu S, Luke A, Li X, Feeley BT. T1? imaging demonstrates early changes in the lateral patella in patients with patellofemoral pain and maltracking. Am J Sports Med. 2013 Aug; 41(8):1813-8. PMID: 23845401
94. Souza RB, Feeley BT, Zarins ZA, Link TM, Li X, Majumdar S. T1rho MRI relaxation in knee OA subjects with varying sizes of cartilage lesions. Knee. 2013 Mar; 20(2):113-9.
95. Burghardt AJ, Lee CH, Kuo D, Majumdar S, Imboden JB, Link TM, Li X. Quantitative in vivo HR-pQCT imaging of 3D wrist and metacarpophalangeal joint space width in rheumatoid arthritis. Ann Biomed Eng. 2013 Dec; 41(12):2553-64. PMID: 23887879
96. Patsch JM, Li X, Baum T, Yap SP, Karampinos DC, Schwartz AV, Link TM. Bone marrow fat composition as a novel imaging biomarker in postmenopausal women with prevalent fragility fractures. J Bone Miner Res. 2013 Aug; 28(8):1721-8. PMID: 23558967
97. Kumar D, Subburaj K, Lin W, Karampinos DC, McCulloch CE, Li X, Link TM, Souza RB, Majumdar S. Quadriceps and hamstrings morphology is related to walking mechanics and knee cartilage MRI relaxation times in young adults. J Orthop Sports Phys Ther. 2013 Dec; 43(12):881-90. PMID: 24175607
98. Shet K, Siddiqui SM, Yoshihara H, Kurhanewicz J, Ries M, Li X. High-resolution magic angle spinning NMR spectroscopy of human osteoarthritic cartilage. NMR Biomed. 2012 Apr; 25(4):538-44.
99. Jungmann PM, Li X, Nardo L, Subburaj K, Lin W, Ma CB, Majumdar S, Link TM. Do cartilage repair procedures prevent degenerative meniscus changes?: longitudinal t1? and morphological evaluation with 3.0-T MRI. Am J Sports Med. 2012 Dec; 40(12):2700-8. PMID: 23104606
100. Haughom B, Schairer W, Souza RB, Carpenter D, Ma CB, Li X. Abnormal tibiofemoral kinematics following ACL reconstruction are associated with early cartilage matrix degeneration measured by MRI T1rho. Knee. 2012 Aug; 19(4):482-7.
101. Schairer WW, Haughom BD, Morse LJ, Li X, Ma CB. Magnetic resonance imaging evaluation of knee kinematics after anterior cruciate ligament reconstruction with anteromedial and transtibial femoral tunnel drilling techniques. Arthroscopy. 2011 Dec; 27(12):1663-70.
102. Baum T, Yap SP, Karampinos DC, Nardo L, Kuo D, Burghardt AJ, Masharani UB, Schwartz AV, Li X, Link TM. Does vertebral bone marrow fat content correlate with abdominal adipose tissue, lumbar spine bone mineral density, and blood biomarkers in women with type 2 diabetes mellitus? J Magn Reson Imaging. 2012 Jan; 35(1):117-24.
103. Li X, Yu A, Virayavanich W, Noworolski SM, Link TM, Imboden J. Quantitative characterization of bone marrow edema pattern in rheumatoid arthritis using 3 tesla MRI. J Magn Reson Imaging. 2012 Jan; 35(1):211-7.
104. Theologis AA, Schairer WW, Carballido-Gamio J, Majumdar S, Li X, Ma CB. Longitudinal analysis of T(1?) and T(2) quantitative MRI of knee cartilage laminar organization following microfracture surgery. Knee. 2012 Oct; 19(5):652-7.
105. Souza RB, Fang C, Luke A, Wu S, Li X, Majumdar S. Relationship between knee kinetics during jumping tasks and knee articular cartilage MRI T1rho and T2 relaxation times. Clin Biomech (Bristol, Avon). 2012 May; 27(4):403-8.
106. Subburaj K, Souza RB, Stehling C, Wyman BT, Le Graverand-Gastineau MP, Link TM, Li X, Majumdar S. Association of MR relaxation and cartilage deformation in knee osteoarthritis. J Orthop Res. 2012 Jun; 30(6):919-26.
107. Haughom BD, Souza R, Schairer WW, Li X, Benjamin Ma C. Evaluating rotational kinematics of the knee in ACL-ruptured and healthy patients using 3.0 Tesla magnetic resonance imaging. Knee Surg Sports Traumatol Arthrosc. 2012 Apr; 20(4):663-70.
108. Kothari A, Haughom B, Subburaj K, Feeley B, Li X, Ma CB. Evaluating rotational kinematics of the knee in ACL reconstructed patients using 3.0Tesla magnetic resonance imaging. Knee. 2012 Oct; 19(5):648-51.
109. Jones EF, Schooler J, Miller DC, Drake CR, Wahnishe H, Siddiqui S, Li X, Majumdar S. Characterization of human osteoarthritic cartilage using optical and magnetic resonance imaging. Mol Imaging Biol. 2012 Feb; 14(1):32-9.
110. Zuo J, Joseph GB, Li X, Link TM, Hu SS, Berven SH, Kurhanewitz J, Majumdar S. In vivo intervertebral disc characterization using magnetic resonance spectroscopy and t1? imaging: association with discography and oswestry disability index and short form-36 health survey. Spine (Phila Pa 1976). 2012 Feb 1; 37(3):214-21.
111. Souza RB, Baum T, Wu S, Feeley BT, Kadel N, Li X, Link TM, Majumdar S. Effects of unloading on knee articular cartilage t1rho and t2 magnetic resonance imaging relaxation times: a case series. J Orthop Sports Phys Ther. 2012; 42(6):511-20.
112. Subburaj K, Kumar D, Souza RB, Alizai H, Li X, Link TM, Majumdar S. The acute effect of running on knee articular cartilage and meniscus magnetic resonance relaxation times in young healthy adults. Am J Sports Med. 2012 Sep; 40(9):2134-41.
113. Stehling C, Souza RB, Graverand MP, Wyman BT, Li X, Majumdar S, Link TM. Loading of the knee during 3.0T MRI is associated with significantly increased medial meniscus extrusion in mild and moderate osteoarthritis. Eur J Radiol. 2012 Aug; 81(8):1839-45.
114. Cotofana S, Eckstein F, Wirth W, Souza RB, Li X, Wyman B, Hellio-Le Graverand MP, Link T, Majumdar S. In vivo measures of cartilage deformation: patterns in healthy and osteoarthritic female knees using 3T MR imaging. Eur Radiol. 2011 Jun; 21(6):1127-35.
115. Theologis AA, Kuo D, Cheng J, Bolbos RI, Carballido-Gamio J, Ma CB, Li X. Evaluation of bone bruises and associated cartilage in anterior cruciate ligament-injured and -reconstructed knees using quantitative t(1?) magnetic resonance imaging: 1-year cohort study. Arthroscopy. 2011 Jan; 27(1):65-76.
116. Li X, Cheng J, Lin K, Saadat E, Bolbos RI, Jobke B, Ries MD, Horvai A, Link TM, Majumdar S. Quantitative MRI using T1rho and T2 in human osteoarthritic cartilage specimens: correlation with biochemical measurements and histology. Magn Reson Imaging. 2011 Apr; 29(3):324-34.
117. Li X, Kuo D, Theologis A, Carballido-Gamio J, Stehling C, Link TM, Ma CB, Majumdar S. Cartilage in anterior cruciate ligament-reconstructed knees: MR imaging T1{rho} and T2--initial experience with 1-year follow-up. Radiology. 2011 Feb; 258(2):505-14.
118. Tang SY, Souza RB, Ries M, Hansma PK, Alliston T, Li X. Local tissue properties of human osteoarthritic cartilage correlate with magnetic resonance T(1) rho relaxation times. J Orthop Res. 2011 Sep; 29(9):1312-9.
119. Li X, Kuo D, Schafer AL, Porzig A, Link TM, Black D, Schwartz AV. Quantification of vertebral bone marrow fat content using 3 Tesla MR spectroscopy: reproducibility, vertebral variation, and applications in osteoporosis. J Magn Reson Imaging. 2011 Apr; 33(4):974-9.
120. Masharani UB, Maddux BA, Li X, Sakkas GK, Mulligan K, Schambelan M, Goldfine ID, Youngren JF. Insulin resistance in non-obese subjects is associated with activation of the JNK pathway and impaired insulin signaling in skeletal muscle. PLoS One. 2011; 6(5):e19878.
121. Link TM, Li X. Bone marrow changes in osteoarthritis. Semin Musculoskelet Radiol. 2011 Jul; 15(3):238-46.
122. Zhao J, Li X, Bolbos RI, Link TM, Majumdar S. Longitudinal assessment of bone marrow edema-like lesions and cartilage degeneration in osteoarthritis using 3 T MR T1rho quantification. Skeletal Radiol. 2010 Jun; 39(6):523-31.
123. Blumenkrantz G, Zuo J, Li X, Kornak J, Link TM, Majumdar S. In vivo 3.0-tesla magnetic resonance T1rho and T2 relaxation mapping in subjects with intervertebral disc degeneration and clinical symptoms. Magn Reson Med. 2010 May; 63(5):1193-200.
124. Wirth W, Frobell RB, Souza RB, Li X, Wyman BT, Le Graverand MP, Link TM, Majumdar S, Eckstein F. A three-dimensional quantitative method to measure meniscus shape, position, and signal intensity using MR images: a pilot study and preliminary results in knee osteoarthritis. Magn Reson Med. 2010 May; 63(5):1162-71.
125. Rao MN, Mulligan K, Tai V, Wen MJ, Dyachenko A, Weinberg M, Li X, Lang T, Grunfeld C, Schwarz JM, Schambelan M. Effects of insulin-like growth factor (IGF)-I/IGF-binding protein-3 treatment on glucose metabolism and fat distribution in human immunodeficiency virus-infected patients with abdominal obesity and insulin resistance. J Clin Endocrinol Metab. 2010 Sep; 95(9):4361-6.
126. Luke AC, Stehling C, Stahl R, Li X, Kay T, Takamoto S, Ma B, Majumdar S, Link T. High-field magnetic resonance imaging assessment of articular cartilage before and after marathon running: does long-distance running lead to cartilage damage? Am J Sports Med. 2010 Nov; 38(11):2273-80.
127. Zarins ZA, Bolbos RI, Pialat JB, Link TM, Li X, Souza RB, Majumdar S. Cartilage and meniscus assessment using T1rho and T2 measurements in healthy subjects and patients with osteoarthritis. Osteoarthritis Cartilage. 2010 Nov; 18(11):1408-16.
128. Holtzman DJ, Theologis AA, Carballido-Gamio J, Majumdar S, Li X, Benjamin C. T(1?) and T(2) quantitative magnetic resonance imaging analysis of cartilage regeneration following microfracture and mosaicplasty cartilage resurfacing procedures. J Magn Reson Imaging. 2010 Oct; 32(4):914-23.
129. Souza RB, Stehling C, Wyman BT, Hellio Le Graverand MP, Li X, Link TM, Majumdar S. The effects of acute loading on T1rho and T2 relaxation times of tibiofemoral articular cartilage. Osteoarthritis Cartilage. 2010 Dec; 18(12):1557-63.
130. Stahl R, Luke A, Li X, Carballido-Gamio J, Ma CB, Majumdar S, Link TM. T1rho, T2 and focal knee cartilage abnormalities in physically active and sedentary healthy subjects versus early OA patients--a 3.0-Tesla MRI study. Eur Radiol. 2009 Jan; 19(1):132-43.
131. Lozano J, Saadat E, Li X, Majumdar S, Ma CB. Magnetic resonance T(1 rho) imaging of osteoarthritis: a rabbit ACL transection model. Magn Reson Imaging. 2009 Jun; 27(5):611-6.
132. Li X, Majumdar S. Section IV: Macromolecular imaging of cartilage. J Bone Joint Surg Am. 2009 Feb; 91 Suppl 1:43.
133. Taylor C, Carballido-Gamio J, Majumdar S, Li X. Comparison of quantitative imaging of cartilage for osteoarthritis: T2, T1rho, dGEMRIC and contrast-enhanced computed tomography. Magn Reson Imaging. 2009 Jul; 27(6):779-84.
134. Hansma P, Yu H, Schultz D, Rodriguez A, Yurtsev EA, Orr J, Tang S, Miller J, Wallace J, Zok F, Li C, Souza R, Proctor A, Brimer D, Nogues-Solan X, Mellbovsky L, Peña MJ, Diez-Ferrer O, Mathews P, Randall C, Kuo A, Chen C, Peters M, Kohn D, Buckley J, Li X, Pruitt L, Diez-Perez A, Alliston T, Weaver V, Lotz J. The tissue diagnostic instrument. Rev Sci Instrum. 2009 May; 80(5):054303.
135. Li X, Pai A, Blumenkrantz G, Carballido-Gamio J, Link T, Ma B, Ries M, Majumdar S. Spatial distribution and relationship of T1rho and T2 relaxation times in knee cartilage with osteoarthritis. Magn Reson Med. 2009 Jun; 61(6):1310-8.
136. Zuo J, Saadat E, Romero A, Loo K, Li X, Link TM, Kurhanewicz J, Majumdar S. Assessment of intervertebral disc degeneration with magnetic resonance single-voxel spectroscopy. Magn Reson Med. 2009 Nov; 62(5):1140-6.
137. Li X, Youngren JF, Hyun B, Sakkas GK, Mulligan K, Majumdar S, Masharani UB, Schambelan M, Goldfine ID. Technical evaluation of in vivo abdominal fat and IMCL quantification using MRI and MRSI at 3 T. Magn Reson Imaging. 2008 Feb; 26(2):188-97.
138. Zhou ZY, Shan H, Ringgaard S, Zou XN, Zou LJ, Li HS, Li X, Stodkilde-Jorgensen H, Bunger C. Chin J Radiol. Three-dimensional spin-lattice relaxation time in the rotating frame and quantitation of articular cartilage at 7.0 T MR. 2008; 10(42):1101-5.
139. Zuo J, Bolbos R, Hammond K, Li X, Majumdar S. Reproducibility of the quantitative assessment of cartilage morphology and trabecular bone structure with magnetic resonance imaging at 7 T. Magn Reson Imaging. 2008 May; 26(4):560-6.
140. Li X, Han ET, Busse RF, Majumdar S. In vivo T(1rho) mapping in cartilage using 3D magnetization-prepared angle-modulated partitioned k-space spoiled gradient echo snapshots (3D MAPSS). Magn Reson Med. 2008 Feb; 59(2):298-307.
141. Bolbos RI, Zuo J, Banerjee S, Link TM, Ma CB, Li X, Majumdar S. Relationship between trabecular bone structure and articular cartilage morphology and relaxation times in early OA of the knee joint using parallel MRI at 3 T. Osteoarthritis Cartilage. 2008 Oct; 16(10):1150-9.
142. Saadat E, Jobke B, Chu B, Lu Y, Cheng J, Li X, Ries MD, Majumdar S, Link TM. Diagnostic performance of in vivo 3-T MRI for articular cartilage abnormalities in human osteoarthritic knees using histology as standard of reference. Eur Radiol. 2008 Oct; 18(10):2292-302.
143. Pai A, Li X, Majumdar S. A comparative study at 3 T of sequence dependence of T2 quantitation in the knee. Magn Reson Imaging. 2008 Nov; 26(9):1215-20.
144. Carballido-Gamio J, Link TM, Li X, Han ET, Krug R, Ries MD, Majumdar S. Feasibility and reproducibility of relaxometry, morphometric, and geometrical measurements of the hip joint with magnetic resonance imaging at 3T. J Magn Reson Imaging. 2008 Jul; 28(1):227-35.
145. Li X, Ma BC, Bolbos RI, Stahl R, Lozano J, Zuo J, Lin K, Link TM, Safran M, Majumdar S. Quantitative assessment of bone marrow edema-like lesion and overlying cartilage in knees with osteoarthritis and anterior cruciate ligament tear using MR imaging and spectroscopic imaging at 3 Tesla. J Magn Reson Imaging. 2008 Aug; 28(2):453-61.
146. Bolbos RI, Link TM, Ma CB, Majumdar S, Li X. T1rho relaxation time of the meniscus and its relationship with T1rho of adjacent cartilage in knees with acute ACL injuries at 3 T. Osteoarthritis Cartilage. 2009 Jan; 17(1):12-8.
147. Rauscher I, Stahl R, Cheng J, Li X, Huber MB, Luke A, Majumdar S, Link TM. Meniscal measurements of T1rho and T2 at MR imaging in healthy subjects and patients with osteoarthritis. Radiology. 2008 Nov; 249(2):591-600.
148. Bolbos RI, Ma CB, Link TM, Majumdar S, Li X. In vivo T1rho quantitative assessment of knee cartilage after anterior cruciate ligament injury using 3 Tesla magnetic resonance imaging. Invest Radiol. 2008 Nov; 43(11):782-8.
149. Li X, Ma CB, Link TM, Castillo DD, Blumenkrantz G, Lozano J, Carballido-Gamio J, Ries M, Majumdar S. In vivo T(1rho) and T(2) mapping of articular cartilage in osteoarthritis of the knee using 3 T MRI. Osteoarthritis Cartilage. 2007 Jul; 15(7):789-97.
150. Stahl R, Blumenkrantz G, Carballido-Gamio J, Zhao S, Munoz T, Hellio Le Graverand-Gastineau MP, Li X, Majumdar S, Link TM. MRI-derived T2 relaxation times and cartilage morphometry of the tibio-femoral joint in subjects with and without osteoarthritis during a 1-year follow-up. Osteoarthritis Cartilage. 2007 Nov; 15(11):1225-34.
151. Zuo J, Li X, Banerjee S, Han E, Majumdar S. Parallel imaging of knee cartilage at 3 Tesla. J Magn Reson Imaging. 2007 Oct; 26(4):1001-9.
152. Lozano J, Li X, Link TM, Safran M, Majumdar S, Ma CB. Detection of posttraumatic cartilage injury using quantitative T1rho magnetic resonance imaging. A report of two cases with arthroscopic findings. J Bone Joint Surg Am. 2006 Jun; 88(6):1349-52.
153. Blumenkrantz G, Li X, Han ET, Newitt DC, Crane JC, Link TM, Majumdar S. A feasibility study of in vivo T1rho imaging of the intervertebral disc. Magn Reson Imaging. 2006 Oct; 24(8):1001-7.
154. Majumdar S, Li X, Blumenkrantz G, Saldanha K, Ma CB, Kim H, Lozano J, Link T. MR imaging and early cartilage degeneration and strategies for monitoring regeneration. J Musculoskelet Neuronal Interact. 2006 Oct-Dec; 6(4):382-4.
155. Li X, Han ET, Ma CB, Link TM, Newitt DC, Majumdar S. In vivo 3T spiral imaging based multi-slice T(1rho) mapping of knee cartilage in osteoarthritis. Magn Reson Med. 2005 Oct; 54(4):929-36.
156. Li X, Vigneron DB, Cha S, Graves EE, Crawford F, Chang SM, Nelson SJ. Relationship of MR-derived lactate, mobile lipids, and relative blood volume for gliomas in vivo. AJNR Am J Neuroradiol. 2005 Apr; 26(4):760-9.
157. Li X, Jin H, Lu Y, Oh J, Chang S, Nelson SJ. Identification of MRI and 1H MRSI parameters that may predict survival for patients with malignant gliomas. NMR Biomed. 2004 Feb; 17(1):10-20.
158. Pirzkall A, Li X, Oh J, Chang S, Berger MS, Larson DA, Verhey LJ, Dillon WP, Nelson SJ. 3D MRSI for resected high-grade gliomas before RT: tumor extent according to metabolic activity in relation to MRI. Int J Radiat Oncol Biol Phys. 2004 May 1; 59(1):126-37.
159. Oh J, Henry RG, Pirzkall A, Lu Y, Li X, Catalaa I, Chang S, Dillon WP, Nelson SJ. Survival analysis in patients with glioblastoma multiforme: predictive value of choline-to-N-acetylaspartate index, apparent diffusion coefficient, and relative cerebral blood volume. J Magn Reson Imaging. 2004 May; 19(5):546-54.
160. Pirzkall A, Nelson SJ, McKnight TR, Takahashi MM, Li X, Graves EE, Verhey LJ, Wara WW, Larson DA, Sneed PK. Metabolic imaging of low-grade gliomas with three-dimensional magnetic resonance spectroscopy. Int J Radiat Oncol Biol Phys. 2002 Aug 1; 53(5):1254-64.
161. Nelson SJ, Graves E, Pirzkall A, Li X, Antiniw Chan A, Vigneron DB, McKnight TR. In vivo molecular imaging for planning radiation therapy of gliomas: an application of 1H MRSI. J Magn Reson Imaging. 2002 Oct; 16(4):464-76.
162. Li X, Lu Y, Pirzkall A, McKnight T, Nelson SJ. Analysis of the spatial characteristics of metabolic abnormalities in newly diagnosed glioma patients. J Magn Reson Imaging. 2002 Sep; 16(3):229-37.
163. Li X, Hu G, Gao S. Design and implementation of a novel compression method in a tele-ultrasound system. IEEE Trans Inf Technol Biomed. 1999 Sep; 3(3):205-13.